Chemically modified heparin improves hepatocellular function, cardiac output, and microcirculation after trauma-hemorrhage and resuscitation

Therapeutic interventions to restore microcirculatory perfusion following experimental hemorrhagic shock and fluid resuscitation: A systematic review

“…Three studies tested the effect of heparin and chemically modified heparin on hepatic, intestinal, renal, and splenic blood flow (Figure 2, Table ) 34‐36 . Overall, they reported that the chemically modified variant of heparin was primarily effective in restoring blood flow following hemorrhagic shock and fluid resuscitation.…”

“…Although this was confirmed by Wang et al, 34 the anticoagulant properties of heparin exclude its use in the clinical setting of hemorrhage and trauma. In this context, the same group investigated the effect of chemically modified heparin with reduced anticoagulant properties 35,36 . Treatment with this compound also restored renal, splenic, and intestinal microvascular blood flow and is proposed to function via inhibition of complement activation 72 .…”

Therapeutic interventions to restore microcirculatory perfusion following experimental hemorrhagic shock and fluid resuscitation: A systematic review

“…Three studies tested the effect of heparin and chemically modified heparin on hepatic, intestinal, renal, and splenic blood flow (Figure 2, Table ) 34‐36 . Overall, they reported that the chemically modified variant of heparin was primarily effective in restoring blood flow following hemorrhagic shock and fluid resuscitation.…”

“…Although this was confirmed by Wang et al, 34 the anticoagulant properties of heparin exclude its use in the clinical setting of hemorrhage and trauma. In this context, the same group investigated the effect of chemically modified heparin with reduced anticoagulant properties 35,36 . Treatment with this compound also restored renal, splenic, and intestinal microvascular blood flow and is proposed to function via inhibition of complement activation 72 .…”

An estrogen (17α-ethinyl estradiol-3-sulfate) reduces mortality in a swine model of multiple injuries and hemorrhagic shock

“…In addition, the administration of heparin used to help facilitate the hemorrhage can be a point of consideration given previous findings demonstrating improved microcirculatory and hemodynamic effects after heparinization 42–45 . However, it is important to note that those studies used heparin doses 10 to 20 times of that used in the current study.…”

Adverse Effect of Heparin on Antithrombin Action during Endotoxemia: Microhemodynamic and Cellular Mechanisms

“…Such a proinflammatory heparin action seems, however, highly unlikely, because heparins have even been shown to reduce endotoxin-induced proinflammatory cytokine synthesis and to effectively bind to tumor necrosis factor (37). Moreover, different heparins have been used in animal models of sepsis producing favourable results or at least no adverse effects per se (38,39). Therefore, it seems to be more likely that heparin directly interferes with microcirculatory AT action.…”

Therapeutic interventions to restore microcirculatory perfusion following experimental hemorrhagic shock and fluid resuscitation: A systematic review

“…Three studies tested the effect of heparin and chemically modified heparin on hepatic, intestinal, renal, and splenic blood flow (Figure 2, Table ) 34‐36 . Overall, they reported that the chemically modified variant of heparin was primarily effective in restoring blood flow following hemorrhagic shock and fluid resuscitation.…”

“…Although this was confirmed by Wang et al, 34 the anticoagulant properties of heparin exclude its use in the clinical setting of hemorrhage and trauma. In this context, the same group investigated the effect of chemically modified heparin with reduced anticoagulant properties 35,36 . Treatment with this compound also restored renal, splenic, and intestinal microvascular blood flow and is proposed to function via inhibition of complement activation 72 .…”

An estrogen (17α-ethinyl estradiol-3-sulfate) reduces mortality in a swine model of multiple injuries and hemorrhagic shock

“…In addition, the administration of heparin used to help facilitate the hemorrhage can be a point of consideration given previous findings demonstrating improved microcirculatory and hemodynamic effects after heparinization 42–45 . However, it is important to note that those studies used heparin doses 10 to 20 times of that used in the current study.…”

Adverse Effect of Heparin on Antithrombin Action during Endotoxemia: Microhemodynamic and Cellular Mechanisms

“…Such a proinflammatory heparin action seems, however, highly unlikely, because heparins have even been shown to reduce endotoxin-induced proinflammatory cytokine synthesis and to effectively bind to tumor necrosis factor (37). Moreover, different heparins have been used in animal models of sepsis producing favourable results or at least no adverse effects per se (38,39). Therefore, it seems to be more likely that heparin directly interferes with microcirculatory AT action.…”

Therapeutic interventions to restore microcirculatory perfusion following experimental hemorrhagic shock and fluid resuscitation: A systematic review

“…Three studies tested the effect of heparin and chemically modified heparin on hepatic, intestinal, renal, and splenic blood flow (Figure 2, Table ) 34‐36 . Overall, they reported that the chemically modified variant of heparin was primarily effective in restoring blood flow following hemorrhagic shock and fluid resuscitation.…”

“…Although this was confirmed by Wang et al, 34 the anticoagulant properties of heparin exclude its use in the clinical setting of hemorrhage and trauma. In this context, the same group investigated the effect of chemically modified heparin with reduced anticoagulant properties 35,36 . Treatment with this compound also restored renal, splenic, and intestinal microvascular blood flow and is proposed to function via inhibition of complement activation 72 .…”

An estrogen (17α-ethinyl estradiol-3-sulfate) reduces mortality in a swine model of multiple injuries and hemorrhagic shock

“…In addition, the administration of heparin used to help facilitate the hemorrhage can be a point of consideration given previous findings demonstrating improved microcirculatory and hemodynamic effects after heparinization 42–45 . However, it is important to note that those studies used heparin doses 10 to 20 times of that used in the current study.…”

Adverse Effect of Heparin on Antithrombin Action during Endotoxemia: Microhemodynamic and Cellular Mechanisms

“…Such a proinflammatory heparin action seems, however, highly unlikely, because heparins have even been shown to reduce endotoxin-induced proinflammatory cytokine synthesis and to effectively bind to tumor necrosis factor (37). Moreover, different heparins have been used in animal models of sepsis producing favourable results or at least no adverse effects per se (38,39). Therefore, it seems to be more likely that heparin directly interferes with microcirculatory AT action.…”