Chemical study of plants of the Mongolian flora coumarins ofStellera chamaejasme: The structure of chamaejasmoside — A new bicoumarin glycoside

Narantuya, Samdan; Batsurén, D.; Rashkes, Ya. V.; Mil'grom, E. G.

doi:10.1007/bf00630004

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…A new biscoumarin has been isolated from aerial part of Stellera chamaejasmoside 260 , while 11-methylgerberinol 261 was isolated from the roots of Diospyros kakis . The structure of 261 was established on the basis of its synthesis (Figure ).…”

Section: Bis- and Trischromenesmentioning

confidence: 99%

Natural and Synthetic Chromenes, Fused Chromenes, and Versatility of Dihydrobenzo[h]chromenes in Organic Synthesis

2014

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Section: Bis- and Trischromenesmentioning

confidence: 99%

Natural and Synthetic Chromenes, Fused Chromenes, and Versatility of Dihydrobenzo[h]chromenes in Organic Synthesis

2014

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“…It has also been found that the methanol extract of the root of Stellera chamaejasme L. showed significant antitumor activities [ 29 ]. Chemical constituent investigations indicated S. chamaejasme L. is rich in dicoumarin and biflavonones which have been considered as being responsible for the beneficial effects of S. chamaejasme L. on human health [ 30 , 31 ]. Daphnoretin ( Figure 1 ) is a natural dicoumarin constituent of S. chamaejasme L. with certain anti-HBV activity [ 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Daphnoretin Induces Cell Cycle Arrest and Apoptosis in Human Osteosarcoma (HOS) Cells

2012

Molecules

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In this study antiproliferation, cell cycle arrest and apoptosis induced by daphnoretin in human osteosarcoma (HOS) cells were investigated. Antiproliferative activity was measured with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The IC50 value of daphnoretin was 3.89 μM after 72 h treatment. Induction of apoptosis was evidenced by apoptotic body appearance and Annexin V-FITC/PI apoptosis detection kit. Flow cytometric analysis indicated daphnoretin arrested the cell cycle in the G2/M phase. Western-blot assay showed that the G2/M phase arrest was accompanied by down-regulation of cdc2, cyclin A and cyclin B1. Moreover, daphnoretin inhibited Bcl-2 expression and induced Bax expression to desintegrate the outer mitochondrial membrane and causing cytochrome c release. Mitochondrial cytochrome c release was associated with the activation of caspase-9 and caspase-3 cascade. Our results demonstrated that daphnoretin caused death of HOS cells by blocking cells successively in G2/M phases and activating the caspase-3 pathway.

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Diversity of Chemical Constituents from Saxifraga Montana H.

Liu

Shi

2008

J Chinese Chemical Soc

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A thorough phytochemical investigation of the whole plant of Saxifraga montana H. afforded a new glucoside, methyl 6″‐O‐(E)‐p‐hydroxycinnamoxyl‐glucosyringate (1), and seventeen known natural products, 3‐methyl‐6‐methoxy‐3,4‐dihydroisocoumarin‐8‐O‐β‐D‐glucospyranoside (2), gallic acid (3), glucosyringic acid (4), daphnoretin (5), chamaejasmoside (6), myricetin (7), quercetin (8), quercetin‐3‐O‐β‐D‐galactopyranoside (9), quercetin‐3‐O‐α‐L‐arabinoside (10), quercetin‐3‐O‐β‐D‐glucospyranoside (11), rutin (12), quercetin‐3‐O‐β‐D‐glucopyranosyl (6‐1) glucopyranoside (13), ursolic acid (14), 5,28‐stigmastadien‐3β‐ol (15), β‐sitosterol (16), β‐daucosterin (17), 6′‐palmitoxyl‐β‐daucosterin (18). On the basis of various spectroscopic methods, especially intensive 2D‐NMR (COSY, HMQC and HMBC), FAB‐MS and HR‐ESI‐MS techniques, their structures were elucidated.

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Chemical study of plants of the Mongolian flora coumarins ofStellera chamaejasme: The structure of chamaejasmoside — A new bicoumarin glycoside

Cited by 6 publications

References 4 publications

Natural and Synthetic Chromenes, Fused Chromenes, and Versatility of Dihydrobenzo[h]chromenes in Organic Synthesis

Natural and Synthetic Chromenes, Fused Chromenes, and Versatility of Dihydrobenzo[h]chromenes in Organic Synthesis

Daphnoretin Induces Cell Cycle Arrest and Apoptosis in Human Osteosarcoma (HOS) Cells

Diversity of Chemical Constituents from Saxifraga Montana H.

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