volume 55, issue 19, P8260-8271 2012
DOI: 10.1021/jm301204r
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Abstract: Drugs typically exert desired and undesired biological effects by virtue of binding interactions with protein target(s) and off-target(s), providing evidence for drug efficacy and toxicity. Pioglitazone and rosiglitazone possess a common functional core, glitazone, which is considered a privileged scaffold upon which to build a drug selective for a given target – in this case PPARγ. Herein, we report a retrospective analysis of two variants of the glitazone scaffold, pioglitazone and rosiglitazone, in an effo…

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