Chemical profiling of fingerprints using mass spectrometry

Helmond, Ward van; Herwijnen, Annemijn W. van; Riemsdijk, Joëlle J.H. van; Bochove, Marc A. van; Poot, C.J. de; Puit, Marcel de

doi:10.1016/j.forc.2019.100183

Cited by 26 publications

(37 citation statements)

References 64 publications

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“…Every time we touch a surface, we leave small amounts of endogeneous and exogenous compounds. 27 We have applied the developed GPME probes to collect traces of molecules from the daily use objects such as computer keyboard, mouse, and laboratory bench. Subsequently, we implemented MS to analyze the resulting extracts from hydrogel disks.…”

Section: Results and Discussionmentioning

confidence: 99%

“…A potentially interesting application of GPME is tracing human skin metabolites present on surfaces with fingerprints. Every time we touch a surface, we leave small amounts of endogeneous and exogenous compounds . We have applied the developed GPME probes to collect traces of molecules from the daily use objects such as computer keyboard, mouse, and laboratory bench.…”

Section: Results and Discussionmentioning

confidence: 99%

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Agarose-Based Gel-Phase Microextraction Technique for Quick Sampling of Polar Analytes Adsorbed on Surfaces

Liao

Urban

2019

ACS Omega

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Sampling and extraction of chemical residues present on flat or curved surfaces as well as touch-sensitive objects are challenging. Hydrogels are characterized by high mechanical flexibility and water content. Thus, they are an ideal medium for transferring water-soluble analytes from a sampled surface to the next stage of an analytical workflow. Here, we demonstrate gel-phase microextraction (GPME), in which disks of blended hydrogels are utilized to lift traces of water-soluble substances adsorbed on surfaces. The protocol has been optimized in a series of tests involving fluorometric and mass spectrometric measurements. Compared with the pure agarose hydrogel, most of the tested blended hydrogels provide a higher efficiency for the sampling/extraction of a model analyte, fluorescein. The blended hydrogel disks are incorporated into three-dimensional (3D)-printed acrylonitrile–butadiene–styrene chips to create easy-to-use sampling probes. We exemplify the suitability of this improved GPME approach in sampling chemical residues present on the skin, glass, and daily use objects. In these tests, the extracts were analyzed on a triple quadrupole mass spectrometer fitted with an electrospray ion source operated in the positive- and negative-ion modes. The method enabled the detection of diclofenac on excised porcine skin fragments exposed to a topical nonsteroidal anti-inflammatory drug and sweat residues (lactic acid) left on surfaces touched by humans. The limits of detection for diclofenac and lactic acid in hydrogel extract were 6.4 × 10–6 and 2.1 × 10–5 M, respectively. In a model experiment, conducted using the presented approach, the amount of lactic acid on a glass slide with fingerprints was estimated to be ∼1.4 × 10–7 mol cm–2.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Results and Discussionmentioning

confidence: 99%

Agarose-Based Gel-Phase Microextraction Technique for Quick Sampling of Polar Analytes Adsorbed on Surfaces

Liao

Urban

2019

ACS Omega

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“…For example, there is growing evidence that fingerprints can be used to convey information about the donor, such as use of medication [1][2][3][4][5] and gender. [6][7][8][9][10][11][12] There is also growing evidence to support the concept of using a fingerprint to provide information concerning the circumstances of depositionso-called "activity level information". [13][14][15] Meanwhile, in its latest World Drug Report 2020, the United Nations Office on Drug and Crime (UNODC) reports that as of 2018 approximately 5.3% (or 269 million people) of the global population aged 15-64 had used illicit drugs in the previous year.…”

Section: Introductionmentioning

confidence: 99%

Imaging mass spectrometry: a new way to distinguish dermal contact from administration of cocaine, using a single fingerprint

Costa

Jang

Jesus

et al. 2021

Analyst

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“…It is useful to note that although males are statistically more likely to be involved in criminal activities than women, research has persisted in this area for multiple reasons [ 13 ]. Firstly, it is believed that analysis of fingermark content can be instrumental in cases where there is no reference fingerprint in a database to which a crime scene fingerprint could be compared for individualization [ 14 ]. Additionally, analysis of deposits could provide biological information about the perpetrator in cases where there is distortion or deterioration of fingermarks [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Device for the Identification of Biological Sex by Analysis of Latent Fingermark Deposits

2021

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To date, most research regarding amino acid detection and quantification in fingermarks relies on spectrometric methods. Herein, the Sakaguchi colorimetric test was adapted to a rotationally-driven microfluidic platform and used to detect and quantify arginine in fingermarks deposited by male and female donors. A red color indicates the presence of arginine in a given sample following the reaction, and the intensity of this color is linearly proportional to the concentration. Objective detection and quantification of arginine were accomplished using image analysis software (freeware) based on this colorimetric result. The mean concentrations obtained in a blind study were 96.4 ± 5.1 µM for samples from female donors and 55.3 ± 5.3 µM for samples from males. These were not statistically different from the literature values of 94.8 µM ± 12.9 µM for females (p = 0.908) and 54.0 ± 12.6 µM for males (p = 0.914), respectively (± SEM in all cases). Conversely, the experimental means from males and female samples were statistically different from each other (p < 0.001). Objective differentiation between male and female fingermark deposits was achieved in a blind study with 93% accuracy. Additionally, the method was compatible both with samples lifted from common surfaces and with magnetically-powdered samples.

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Chemical profiling of fingerprints using mass spectrometry

Cited by 26 publications

References 64 publications

Agarose-Based Gel-Phase Microextraction Technique for Quick Sampling of Polar Analytes Adsorbed on Surfaces

Agarose-Based Gel-Phase Microextraction Technique for Quick Sampling of Polar Analytes Adsorbed on Surfaces

Imaging mass spectrometry: a new way to distinguish dermal contact from administration of cocaine, using a single fingerprint

Microfluidic Device for the Identification of Biological Sex by Analysis of Latent Fingermark Deposits

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