Chemical identity, function and regulation of enteroendocrine peptides in insects

Wegener, Christian; Veenstra, Jan A.

doi:10.1016/j.cois.2015.07.003

Cited by 37 publications

(27 citation statements)

References 55 publications

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“…gratiosa , similar to previous reports for other Orthoptera members [5, 12, 14, 16]. Endocrine cells in insect midgut perform important roles by releasing various peptides in many key physiological functions, and the kind and distribution of regulatory peptides vary with different species [17]. Thus, further research in this area would be needed.…”

Section: Discussionsupporting

confidence: 83%

Morphology and fine organization of the midgut of Gampsocleis gratiosa (Orthoptera: Tettigoniidae)

Zhang

Yang

et al. 2018

PLoS ONE

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The morphology and ultrastructure of the midgut of Gampsocleis gratiosa (Orthoptera: Tettigoniidae) was examined by light and electron microscopy. The midgut consists of two bulbous gastric caeca and a tubular ventriculus. The general organization of the gastric caeca is similar to that of the ventriculus. They are composed of a peritrophic membrane, an epithelium, a basal lamina and muscle layer from the inside to outside. Three types of cells were identified: regenerative, principal, and endocrine. Regenerative cells occur in groups (called nidi) at the base of principal cells. Principal cells grow from regenerative cells. Rare endocrine cells are scattered throughout the epithelium. Principal cells exhibit intense secretory activity, and regional differences in their ultrastructure were observed along the entire midgut. The microvilli are longer than those in any other region in the posterior region of the midgut. Lysosomes, multivesicular bodies (MVBs), autophagosomes, abundant Golgi apparatuses and lipid droplets primarily occur in the gastric caeca. Three pathways of secretion (merocrine, apocrine and holocrine) occur within the midgut epithelium, and a distinctive type of apocrine bleb was found in the gastric caeca. Therefore, these gastric caeca may be evolving toward a special type of gland.

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Section: Discussionsupporting

confidence: 83%

Morphology and fine organization of the midgut of Gampsocleis gratiosa (Orthoptera: Tettigoniidae)

Zhang

Yang

et al. 2018

PLoS ONE

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“…Most previous studies focused on the functional roles of regulatory peptides in the central nervous system. In recent years, the roles of regulatory peptides in enteroendocrine cells have been gaining interest ( Wegener and Veenstra, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

A Systematic Analysis of Drosophila Regulatory Peptide Expression in Enteroendocrine Cells

Kim

Kwon

2016

Molecules and Cells

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The digestive system is gaining interest as a major regulator of various functions including immune defense, nutrient accumulation, and regulation of feeding behavior, aside from its conventional function as a digestive organ. The Drosophila midgut epithelium is completely renewed every 1–2 weeks due to differentiation of pluripotent intestinal stem cells in the midgut. Intestinal stem cells constantly divide and differentiate into enterocytes that secrete digestive enzymes and absorb nutrients, or enteroendocrine cells that secrete regulatory peptides. Regulatory peptides have important roles in development and metabolism, but study has mainly focused on expression and functions in the nervous system, and not much is known about the roles in endocrine functions of enteroendocrine cells. We systemically examined the expression of 45 regulatory peptide genes in the Drosophila midgut, and verified that at least 10 genes are expressed in the midgut enteroendocrine cells through RT-PCR, in situ hybridization, antisera, and 25 regulatory peptide-GAL transgenes. The Drosophila midgut is highly compartmentalized, and individual peptides in enteroendocrine cells were observed to express in specific regions of the midgut. We also confirmed that some peptides expressed in the same region of the midgut are expressed in mutually exclusive enteroendocrine cells. These results indicate that the midgut enteroendocrine cells are functionally differentiated into different subgroups. Through this study, we have established a basis to study regulatory peptide functions in enteroendocrine cells as well as the complex organization of enteroendocrine cells in the Drosophila midgut.

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“…Another layer of complexity is added when a neuropeptide additionally acts systemically as a hormone released by neurosecretory cells or by enteroendocrine cells (EECs) of the intestine. In the latter case the peptide may target intestinal cells, the central nervous system (CNS), and other tissues to ensure nutrient-dependent inter-organ communication [7][8][9]. Furthermore, a neuropeptide can play very different roles depending on stage in life cycle.…”

Section: Introductionmentioning

confidence: 99%

Neuropeptides in modulation of Drosophila behavior: how to get a grip on their pleiotropic actions

Nässel

Pauls

Huetteroth

2019

Preprint

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Neuropeptides constitute a large and diverse class of signaling molecules that are produced by many types of neurons, neurosecretory cells, endocrines and other cells. Many neuropeptides display pleiotropic actions either as neuromodulators, co-transmitters or circulating hormones, while some play these roles concurrently. Here, we highlight pleiotropic functions of neuropeptides and different levels of neuropeptide signaling in the brain, from context-dependent orchestrating signaling by higher order neurons, to local executive modulation in specific circuits. Additionally, orchestrating neurons receive peptidergic signals from neurons conveying organismal internal state cues and relay these to executive circuits. We exemplify these levels of signaling with four neuropeptides, SIFamide, short neuropeptide F, allatostatin-A and leucokinin, each with a specific expression pattern and level of complexity in signaling.

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Chemical identity, function and regulation of enteroendocrine peptides in insects

Cited by 37 publications

References 55 publications

Morphology and fine organization of the midgut of Gampsocleis gratiosa (Orthoptera: Tettigoniidae)

Morphology and fine organization of the midgut of Gampsocleis gratiosa (Orthoptera: Tettigoniidae)

A Systematic Analysis of Drosophila Regulatory Peptide Expression in Enteroendocrine Cells

Neuropeptides in modulation of Drosophila behavior: how to get a grip on their pleiotropic actions

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