Chemical diversity of accessions of the in vivo germplasm bank of Varronia curassavica (Jacq.)

Queiroz, Túlio Barroso; Fonseca, Francine Souza Alves da; Mendes, Aretusa Daniela Resende; Azevedo, Alcinei Místico; Martins, Ernane Ronie

doi:10.4025/actasciagron.v42i1.42726

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…), a similar result to those observed by other authors regarding populations of black sage(Nizio et al, 2015;Oliveira et al, 2020;Queiroz et al, 2019). The substances found with greatest frequency were α-humulene (100% frequency) and germacrene D and caryophyllene oxide (both with 94% frequency).Nizio et al (2015) reported that β-caryophyllene was the substance with greatest frequency (100%), while Oliveira et al (2019) and Queiroz et al (2019) reported 100% frequency of αhumulene and β-caryophyllene.…”

supporting

confidence: 91%

Chemodiversity and trypanocidal activity of the essential oils of tropical black sage

de Medeiros,

Nascimento,

Duarte-Junior

et al. 2024

Preprint

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Tropical black sage (Varronia curassavica Jacq.) is a species native to ecosystems subject to strong anthropic action, and thus is at risk of genetic erosion. However, little is known about this important genetic resource, with possible uses in the aromas, fragrances and pharmaceutical sectors. The objective of this work was to prospect and study native specimens of tropical black sage regarding the concentration, chemical profile and trypanocidal activity of the essential oils (EOs). For this purpose, we collected in situ 47 specimens. The EOs were obtained by distillation from leaves, quantified, and analyzed by GC-FID and GC-MS. The resulting data were submitted to descriptive statistical and multivariate analyses. The concentration of EOs ranged from 0.3 to 4.2% based on dry leaves. The EOs had average contents of 33.4 and 44.9% of oxygenated and non-oxygenated sesquiterpenes, respectively. The concentration of the substance α-humulene varied from 0.3 to 11.1%, with frequency of 100%. Cluster analysis indicated the formation of 10 groups with 50% similarity among the EOs samples. The sample with the best trypanocidal activity was ESB45, with IC50% of 74.6 µg/mL and 100% inhibition of the viability of the epimastigote form of Trypanosoma cruzi at the concentration of 300 µg/mL. Tropical black sage is a source of oxygenated sesquiterpenes, an important chemical class for synthesis and development of medicines. For this reason, efforts are necessary to preserve the genetic information about the species.

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supporting

confidence: 91%

Chemodiversity and trypanocidal activity of the essential oils of tropical black sage

de Medeiros,

Nascimento,

Duarte-Junior

et al. 2024

Preprint

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“…The compositions varied according to the plant age, mainly for less abundant molecules, which were detected in some samples and in others could not be accurately identified. α-Pinene was the most abundant compound of V. curassavica EOs obtained from different regions of Brazil (São Paulo, Rio de Janeiro, Minas Gerais, Bahia, Sergipe and Ceará) [3,27,32,33]. On the other hand, plants of the same species cultivated in Minas Gerais and in the southern region of Bahia (Brazil) showed β-pinene, β-caryophyllene and α-humulene as the major chemical compounds, while α-pinene and caryophyllene were also found [33][34][35].…”

Section: Resultsmentioning

confidence: 99%

Influence of Plant Age on Chemical Composition, Antimicrobial Activity and Cytotoxicity of Varronia curassavica Jacq. Essential Oil Produced on an Industrial Scale

Farias¹,

Araújo-Nobre²,

Sobrinho-Júnior

et al. 2023

Agriculture

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Considering the therapeutic potential of Varronia curassavica Jacq. essential oil and the great value in the pharmaceutical market, this study aims to evaluate the influence of plant age on the chemical composition and biological activities of V. curassavica Jacq. essential oil. The plant age is a parameter that can influence the chemical composition of the essential oil, as well as its pharmacological potential. For this purpose, essential oils from aerial parts of V. curassavica produced at different ages (4, 10, 14 and 18 months-age) were used. According to chromatograms obtained by GC-MS, the essential oils were mainly composed of α-pinene, trans-caryophyllene, α-santalene, alloaromadendrene and α-humulene. The chemical composition of V. curassavica essential oils varied qualitatively and quantitatively with the aging of the plants, and the essential oils from plants at 18 month-age appeared to be the most distinct from the others. The tested essential oil samples showed inhibitory activity against Candida albicans (MIC = 1000 µg/mL) but did not show antibacterial activity against the tested bacteria. The cytotoxic activity levels against the murine macrophages varied among the oils extracted from the plants at different ages; the IC50 values of the essential oils increased with age (171.90 µg/mL at 18 month-age). More studies should be carried out to assess whether age also affects the therapeutic effects of essential oils, resulting in the manufacture of plant-derived formulations that balance production costs, toxicity and therapeutic effects.

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“…cadineno, carotol, epóxi-cariofileno e (Z)-y-bisaboleno(Carvalho Júnior et al, 2004;Alves et al, 2019;Queiroz et al 2020). O estudo desenvolvido por Facanali et al (2020) possibilitou a identificação de 135 constituintes do óleo essencial da erva-baleeira com uso da cromatografia gasosa bidimensional.Tabela 2 -Principais compostos químicos presentes no óleo essencial de erva-baleeira (Cordia curassavica (…”

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Erva-Baleeira, Uma Possibilidade Real Da Sociobiodiversidade Para Modelos Sustentáveis De Produção

Hartwig

Rodrigues

Júnior

2020

HOLOS

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A Biodiversidade brasileira é de extrema riqueza e alto potencial para uso econômico, incluindo espécies medicinais. É também uma importante estratégia para o desenvolvimento rural sustentável. Os estudos sobre fitotecnia e produção envolvendo as plantas nativas ainda são escassos perante o universo de possibilidades. O objetivo deste trabalho foi realizar uma revisão da cadeia produtiva da erva-baleeira (Cordia curassavica), como modelo de medicamento fitoterápico originado na flora nativa. A pesquisa foi realizada por meio de revisão da literatura científica, as publicações foram analisadas e agrupadas de acordo com sua especificidade: botânica, ecologia, etnobotânica, fitoquímica e fitotecnia. Constatamos um amplo uso popular da espécie, muitas vezes associada à ação anti-inflamatória, creditado ao alfa-humuleno, encontrado em cerca de 3% do óleo essencial. Outros componentes majoritários do óleo são alfa-pineno, trans-cariofileno e alo-aromadendreno. A erva-baleeira é uma espécie nativa de uso medicinal que apresenta cadeia de produção em avançado estado de estruturação quando comparada a outras da flora brasileira. Na literatura científica existem muitas informações acerca de sua ecologia, aspectos botânicos, uso por populações tradicionais e estudos fitoquímicos, porém são mais raros os estudos pertinentes a produção e as formas de manejo, que ainda ocorre por extrativismo. O extrativismo decorrente da alta demanda para uso na produção de fitoterápicos resulta em um processo de degradação ambiental, que também reflete em aspectos sociais.

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Chemical diversity of accessions of the in vivo germplasm bank of Varronia curassavica (Jacq.)

Cited by 6 publications

References 31 publications

Chemodiversity and trypanocidal activity of the essential oils of tropical black sage

Chemodiversity and trypanocidal activity of the essential oils of tropical black sage

Influence of Plant Age on Chemical Composition, Antimicrobial Activity and Cytotoxicity of Varronia curassavica Jacq. Essential Oil Produced on an Industrial Scale

Erva-Baleeira, Uma Possibilidade Real Da Sociobiodiversidade Para Modelos Sustentáveis De Produção

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