CHEMICAL CONSTITUENTS OF Sinningia mauroana AND SCREENING OF ITS EXTRACTS FOR ANTIMICROBIAL, ANTIOXIDANT AND CYTOTOXIC ACTIVITIES

Winiewski, Vanessa; Serain, Alessandra Freitas; Sá, Eduardo L. de; Salvador, Marcos José; Stefanello, Maria Élida Alves

doi:10.21577/0100-4042.20170478

Cited by 1 publication

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References 26 publications

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“…Altogether, 35 jacaranones were isolated from 37 plant species; three-quarters of the compounds are monomers ( n = 26), and the others are dimers ( n = 9) ( Figure 2 and Figure 3 ). Although the best sources of jacaranones are Asteraceae species, certain species of the Acanthaceae [ 3 ], Bignoniaceae [ 1 , 2 , 37 , 38 , 39 , 40 , 41 ], Delesseriaceae [ 42 ], Gesneriaceae [ 43 , 44 ], Oleaceae [ 45 ], and Theaceae [ 4 , 5 ] families were also found to be sources of jacaranones ( Table 2 ). Among Asteraceae species, the genus Senecio is represented by 20 jacaranone derivative-producing plant species [ 36 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

Jacaranone Derivatives with Antiproliferative Activity from Crepis pulchra and Relevance of This Group of Plant Metabolites

Dávid

Kúsz

Pinke

et al. 2022

Plants

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Jacaranones are a small group of specific plant metabolites with promising biological activities. The occurrence of jacaranones is limited to only a few plant families, with Asteraceae being the most abundant source of these compounds. Therefore, jacaranones can also serve as chemotaxonomic markers. Our phytochemical investigation of Crepis pulchra L. (Asteraceae) resulted in three jacaranone derivatives (jacaranone, 2,3-dihydro-2-hydroxyjacaranone, 2,3-dihydro-2-methoxyjacaranone), and (6R,9S)-3-oxo-α-ionol-β-d-glucopyranoside, fulgidic acid, 12,15-octadecadienoic acid methyl ester, scopoletin and apigenin-7-O-β-d-glucoside. This is the first report on the isolation of jacaranones from a species belonging to the Cichorioideae subfamily of Asteraceae. Jacaranone derivatives were subjected to an in vitro antiproliferative assay against a panel of human cancer cell lines (MCF-7, MDA-MB-231, HeLa, and C33A), revealing high or moderate activities, with IC50 values ranging from 6.3 to 26.5 μM.

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