Chemical constituents from ethyl acetate extract of the stems of Rourea oligophlebia Merr.

Abstract

Rourea oligophlebia (Connaraceae) plant has been traditionally used for the treatment of bleeding and bone fractures. Chemical study on the ethyl acetate extract of the stem of Rourea oligophlebia, collected at Ben En National Park, Thanh Hoa province, have led to the isolation of five compounds including friedelin (1), friedelinol (2), coniferyl alcohol (3), 7α‐hydroxyl‐3β‐sistosterol (4) and scopoletin (5). The structures of these compounds have been elucidated by NMR, MS spectroscopic data and comparison with the reported literatures. This is the first report of chemical study on Rourea oligophlebia stems. Compounds 1‐4 were isolated from Rourea genus for the first time.

Antioxidant, Anti‐Skin‐Aging, Anti‐Inflammatory, and Anti‐Acetylcholinesterase Activities of Rourea oligophlebia Extracts

“…In addition, the genus Rourea is also commonly used in traditional medicine such as R. regusa root for respiratory diseases, R. concolor for kidney disease, and R. mimosoides for bloody diarrhea treatments [10] . Previous studies indicated that the secondary metabolites from R. oligophlebia have antibacterial and cytotoxic properties [9,11] . These results may assist in prescribing oriental traditional medicine, although there is no further scientific evidence from this species.…”

“…[10] Previous studies indicated that the secondary metabolites from R. oligophlebia have antibacterial and cytotoxic properties. [9,11] These results may assist in prescribing oriental traditional medicine, although there is no further scientific evidence from this species. In this study, the in vitro antioxidant, anti-skin-aging, anti-inflammatory, and anti-acetylcholine activities of n-hex, AcOEt, BuOH, MeOH, and aqueous extracts from R. oligophlebia roots were investigated for the first time.…”

“…The stems have been known to be a rich source of phenolic compounds, especially flavonoids, coumarins, anthranoids, steroids, quinone, and fatty acids. Potent biological activity, including antioxidant, anti‐inflammatory, hepatoprotective, anti‐hyperglycemic, and antispasmodic activities have been reported for this genus [9] . In addition, the genus Rourea is also commonly used in traditional medicine such as R. regusa root for respiratory diseases, R. concolor for kidney disease, and R. mimosoides for bloody diarrhea treatments [10] .…”

“…Potent biological activity, including antioxidant, anti-inflammatory, hepatoprotective, antihyperglycemic, and antispasmodic activities have been reported for this genus. [9] In addition, the genus Rourea is also commonly used in traditional medicine such as R. regusa root for respiratory diseases, R. concolor for kidney disease, and R. mimosoides for bloody diarrhea treatments. [10] Previous studies indicated that the secondary metabolites from R. oligophlebia have antibacterial and cytotoxic properties.…”