Chemical Composition, Larvicidal, and Biting Deterrent Activity of Essential Oils of Two Subspecies of<i>Tanacetum argenteum</i>(Asterales: Asteraceae) and Individual Constituents Against<i>Aedes aegypti</i>(Diptera: Culicidae)

Alı, Abbas; Tabanca, Nurhayat; Kürkçüoğlu, Mine; Duran, Ahmet; Blythe, Eugene K.; Khan, Ikhlas A.; Başer, Kemal Hüsnü Can

doi:10.1603/me13249

Cited by 32 publications

(11 citation statements)

References 22 publications

(23 reference statements)

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“…Briefly, the bioassay system consists of six 3 × 4 cm wells each of them containing approximately 6 µL of the feeding solution. As described by Ali et al [46], a feeding solution consisting of CPDA-1 and ATP was used instead of blood. All the compounds were tested in this study and DEET, 97%, N, N-diethyl-meta-toluamide (Cas # 134-62-3, Sigma-Aldrich, St. Louis, MO, USA) at 25 nmol/cm 2 was used as a positive control.…”

Section: In Vitro Klun and Debboun (Kandd) Bioassaymentioning

confidence: 99%

Essential Oil Yield and Composition of the Balkan Endemic Satureja pilosa Velen. (Lamiaceae)

et al. 2020

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Satureja pilosa Velen. senso lato is a Balkan endemic plant that is not well characterized and is found on rocky outcrops of limestone base in Stara Planina (the Balkan Mountains) and the Rhodope Mountains. The objective of this study was to assess the variability of essential oil (EO) content and composition of S. pilosa collected at 33 locations across the Balkan and Rhodope Mountains in Bulgaria using advanced statistical methods including cluster analysis. The EO content in dried aboveground biomass varied from 0.52% to 2.03%. More than 21 EO constituents were identified, belonging to the groups of monoterpenes and sesquiterpenes. The monoterpenes were the predominant class, comprising 84.8% to 96.1% of the total EO. Thymol and carvacrol were the major constituents of the phenolic monoterpenoids. Thymol varied from 36.6% to 67.1% and carvacrol varied from 52.4% to 93.0% of the total oil. p-Cymene also varied widely, from 9.6%–34.0%. There were significant variations between locations and within a location in the EO content and composition. This study identified several chemotypes: (1) thymol and p-cymene; (2) thymol, p-cymene and γ-terpinene; (3) carvacrol and p-cymene; (4) carvacrol, p-cymene and γ-terpinene; and (5) carvacrol. This is the first comprehensive study on the endemic plant S. pilosa that identified several chemotypes based on the EO composition. The S. pilosa EO from the five different chemotypes exhibited larvicidal and mosquito repellent activity against Aedes aegypti. The identified chemotypes can be utilized for the development of new varieties with desirable compositions to meet specific industry needs and new mosquito management control products.

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Section: In Vitro Klun and Debboun (Kandd) Bioassaymentioning

confidence: 99%

Essential Oil Yield and Composition of the Balkan Endemic Satureja pilosa Velen. (Lamiaceae)

et al. 2020

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“…α-Pinene (LC 50 = 49.5 ppm), β-pinene (LC 50 = 35.9 ppm), β-caryophyllene (LC 50 = 26.0 ppm), and caryophyllene oxide (LC 50 = 29.8 ppm) were active as larvicides against Ae. aegypti whereas 1,8-cineole did not show any mortality at the highest screening dose of 125 ppm [19,23]. Monoterpenes that were present in variable concentrations in these essential oils showed larvicidal activity.…”

Section: Discussionmentioning

confidence: 90%

“…α-Phellandrene (BDI = 0.52), (+)-α-pinene (BDI = 0.47), (-)-α-pinene (BDI = 0.41), (+)-β-pinene (BDI = 0.57), (-)-β-pinene (BDI = 0.51), p-cymene (BDI = 0.48), trans-sabinene hydrate (BDI = 0.61) showed biting deterrent activity lower than DEET. β-caryophyllene and caryophyllene oxide with BDI values of 0.54 and 0.66, respectively, were also significantly lower than DEET at 25 nmol/cm 2 and these two sesquiterpenes also did not repel mosquitoes up to the highest dose of 1.5 mg/cm 2 in cloth patch assay [6,[19][20][21][22]. Hexadecanoic acid that was only present in seed essential oil was reported to have biting deterrence lower (PNB = 0.72) than DEET [23].…”

Section: Discussionmentioning

confidence: 98%

Insecticidal and Biting Deterrent Activities of Magnolia grandiflora Essential Oils and Selected Pure Compounds against Aedes aegypti

et al. 2020

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In our natural products screening program for mosquitoes, we tested essential oils extracted from different plant parts of Magnolia grandiflora L. for their insecticidal and biting deterrent activities against Aedes aegypti. Biting deterrence of seeds essential oil with biting deterrence index value of 0.89 was similar to N,N-diethyl-3-methylbenzamide (DEET). All the other oils were active above the solvent control but the activity was significantly lower than DEET. Based on GC-MS analysis, three pure compounds that were only present in the essential oil of seed were further investigated to identify the compounds responsible for biting deterrent activity. 1-Decanol with PNB value of 0.8 was similar to DEET (PNB = 0.8), whereas 1-octanol with PNB value of 0.64 showed biting deterrence lower than 1-decanol and DEET. The activity of 1-heptanol with PNB value of 0.36 was similar to the negative control. Since 1-decanol, which was 3.3% of the seed essential oil, showed biting deterrence similar to DEET as a pure compound, this compound might be responsible for the activity of this oil. In in vitro A & K bioassay, 1-decanol with MED value of 6.25 showed higher repellency than DEET (MED = 12.5). Essential oils of immature and mature fruit showed high toxicity whereas leaf, flower, and seeds essential oils gave only 20%, 0%, and 50% mortality, respectively, at the highest dose of 125 ppm. 1-Decanol with LC50 of 4.8 ppm was the most toxic compound.

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“…Nine thiophenes, with different numbers of thiophene rings, isolated from E. transiliensis exhibited strong larvicidal activity and a positive correlation was reported between the number of thiophene rings and larvicidal activity, with thiophene derivatives composed of more rings demonstrating more activity [90] Tetradecanoic acid (75) showed both larvicidal action (LC 50 131.37 µM) and oviposition attraction (78.2% at 43.79 µM) [136,137]. Other fatty acids, hexadecanoic acid (76) and dodecanoic acid (77) displayed lower attraction: 57.4% for (76) at 3.9 µM and 68.8% for (77) (2,2′-bithiophen-5-yl)-2-hydroxybut-3-yn-1-yl acetate (68) (25.31 µM) and 4-(2,2′-bithiophen-5-yl)but-3-yne-1,2-diol (69) (39.19 µM). Lower larvicidal activity was observed for monothiophenes: 2-chloro-4-[5-(penta-1,3-diyn-1-yl)thiophen-2-yl]but-3-yn-1-yl acetate (70) (49.56 µM); 4-[5-(penta-1,3-diyn-1yl)thiophen-2-yl]but-3-yne-1,2-diyl diacetate (71) (56.02 µM); 4-[5-(penta-1,3-diyn-1-yl)thiophen-2yl]but-3-yne-1,2-diol (72) (56.68 µM); 2-hydroxy-4-[5-(penta-1,3-diyn-1-yl)thiophen-2-yl]but-3-yn-1yl acetate (73) (66.64 µM) and 1-hydroxy-4-[5-(penta-1,3-diyn-1-yl)thiophen-2-yl]but-3-yn-2-yl acetate (74) (71.74 µM) [90].…”

Section: Thiophenes and Acidsmentioning

confidence: 98%

“…Tetradecanoic acid (75) showed both larvicidal action (LC50 131.37 µM) and oviposition attraction (78.2% at 43.79 µM) [136,137]. Other fatty acids, hexadecanoic acid (76) and dodecanoic acid (77) displayed lower attraction: 57.4% for (76) at 3.9 µM and 68.8% for (77) at 249.6 µM [137].…”

Section: Thiophenes and Acidsmentioning

confidence: 99%

Plant Natural Products for the Control of Aedes aegypti: The Main Vector of Important Arboviruses

et al. 2020

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The mosquito species Aedes aegypti is one of the main vectors of arboviruses, including dengue, Zika and chikungunya. Considering the deficiency or absence of vaccines to prevent these diseases, vector control remains an important strategy. The use of plant natural product-based insecticides constitutes an alternative to chemical insecticides as they are degraded more easily and are less harmful to the environment, not to mention their lower toxicity to non-target insects. This review details plant species and their secondary metabolites that have demonstrated insecticidal properties (ovicidal, larvicidal, pupicidal, adulticidal, repellent and ovipositional effects) against the mosquito, together with their mechanisms of action. In particular, essential oils and some of their chemical constituents such as terpenoids and phenylpropanoids offer distinct advantages. Thiophenes, amides and alkaloids also possess high larvicidal and adulticidal activities, adding to the wealth of plant natural products with potential in vector control applications.

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Chemical Composition, Larvicidal, and Biting Deterrent Activity of Essential Oils of Two Subspecies ofTanacetum argenteum(Asterales: Asteraceae) and Individual Constituents AgainstAedes aegypti(Diptera: Culicidae)

Cited by 32 publications

References 22 publications

Essential Oil Yield and Composition of the Balkan Endemic Satureja pilosa Velen. (Lamiaceae)

Essential Oil Yield and Composition of the Balkan Endemic Satureja pilosa Velen. (Lamiaceae)

Insecticidal and Biting Deterrent Activities of Magnolia grandiflora Essential Oils and Selected Pure Compounds against Aedes aegypti

Plant Natural Products for the Control of Aedes aegypti: The Main Vector of Important Arboviruses

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