Chemical Composition, Antimicrobial and Antiprotozoal Activity of Essential Oils From<i>Vernonia brasiliana</i>(Less) Druce (Asteraceae)

Martins, Mário Machado; Aquino, Francisco José Tôrres de; Oliveira, Alberto de; Nascimento, Evandro A.; Chang, Roberto; Borges, Mariane S.; Melo, Geraldo Batista de; Silva, Cláudio V. da; Machado, Fabricio; Morais, Sérgio Antônio Lemos de

doi:10.1080/0972060x.2014.895683

Cited by 11 publications

(13 citation statements)

References 12 publications

(3 reference statements)

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“…Vernonia brasiliana : V. brasiliana is a bush tree observed in the Brazilian savannah, also known as ‘assa-peixe’. The EO from flowers, roots and leaves of V. brasiliana did not display cytotoxicity against Vero (ATCC CCL 81) and RAW 264.7 cell lines, but they showed inhibitory activity against T. cruzi (Martins et al ., 2015). The only study about V. brasiliana , by Martins et al .…”

Section: Discussionmentioning

confidence: 99%

“…The only study about V. brasiliana , by Martins et al . (2015) showed that (a) in the EOs obtained by hydrodistillation, the major components found in the flowers were ( E )-hex-2-enal (4.0%), hexan-1-ol (4.2%), ( Z )-hex- 2-en-1-ol (6.3%) and palmitic acid (8.3%); (b) in the roots, the major components were α -isocomene (15.4%), α -gurjunene (9.6%), β -isocomene (10.3%), trans caryophyllene (10.4%) and palmitic acid (5.3%); (c) the major components of EOs in the leaves were trans -caryophyllene (8.7%), germacrene-D (10.2%) and caryophyllene oxide (4.5%).…”

Section: Discussionmentioning

confidence: 99%

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Effect of essential oils on Leishmania amazonensis: a systematic review

et al. 2020

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This systematic review investigated the evidence for the therapeutic potential of essential oils (EOs) against Leishmania amazonensis. We searched available scientific publications from 2005 to 2019 in the PubMed and Web of Science electronic databases, according to PRISMA statement. The search strategy utilized descriptors and free terms. The EOs effect of 35 species of plants identified in this systematic review study, 45.7% had half of the maximal inhibitory concentration (IC50) 10 < IC50 ⩽ 50 μg mL−1 and 14.3% had a 10 < IC50μg mL−1 for promastigote forms of L. amazonensis. EOs from Cymbopogon citratus species had the lowest IC50 (1.7 μg mL−1). Among the plant species analyzed for activity against intracellular amastigote forms of L. amazonensis, 39.4% had an IC50 10 < IC50 ⩽ 50 μg mL−1, and 33.3% had an IC50 10 < IC50μg mL−1. Aloysia gratissima EO showed the lowest IC50 (0.16 μg mL−1) for intracellular amastigotes. EOs of Chenopodium ambrosioides, Copaifera martii and Carapa guianensis, administered by the oral route, were effective in reducing parasitic load and lesion volume in L. amazonensis-infected BALB/c mice. EOs of Bixa orellana and C. ambrosioides were effective when administered intraperitoneally. Most of the studies analyzed in vitro and in vivo for the risk of bias showed moderate methodological quality. These results indicate a stimulus for the development of new phytotherapy drugs for leishmaniasis treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of essential oils on Leishmania amazonensis: a systematic review

et al. 2020

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“…Previous studies of antiparasitic activities have established that EOs can be highly active (IC 50 < 10 μg/mL), active (IC 50 > 10 < 50 μg/mL), moderately active (IC 50 > 50 < 100 μg/mL) or inactive (IC 50 > 100 μg/mL) (Estevam et al, 2017). Not only EL-EO and ES-EO exhibit strong leishmanicidal activity, but also other species of the family Asteraceae stand out as producers of active EOs against parasites of the genus Leishmania: Artemisia campestris (Aloui et al, 2016), Artemisia herba-alba (Tamargo et al, 2017), Artemisia absinthium (Tamargo et al, 2017), Artemisia abyssinica (Tariku et al, 2010), Vernonia brasiliana (Martins et al, 2015b) and Vernonia polyanthes (Moreira et al, 2017). Leishmanicidal activity exhibited by EOs from E. erythropappus can be explained by the high concentration of α-bisabolol, which had also been previously identified in EOs from Vanillosmopis arborea.…”

Section: Resultsmentioning

confidence: 99%

In vitro evaluation of anticaries, antimycobacterial, antileishmanial and cytotoxic activities of essential oils from Eremanthus erythropappus and of α-bisabolol, their major sesquiterpene

et al. 2020

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Interest in researches into medicinal plants and therapeutic effects of essential oils (EOs) on humans has increased over the last few years. Eremanthus erythropappus, known as candeia, is a Brazilian aromatic herbaceous plant whose α-bisabolol-rich oil has been used in several cosmetic preparations. This paper reports in vitro anticaries, antimycobacterial, antileishmanial and cytotoxic activities of EOs from E. erythropappus leaves (EL-EO) and stalks (ES-EO), besides α-bisabolol, their main sesquiterpene. EL-EO and ES-EO were extracted by hydrodistillation and analyzed by GC-FID and GC-MS. α-Bisabolol, cis-α-bisabolene and β-bisabolene were identified as their major constituents. Antibacterial activity of EOs was evaluated against eight standard strains of pathogens from the American Type Culture Collection (ATCC) by determining minimum inhibitory concentrations (MICs) with the use of the microdilution method. Antibacterial activity was evaluated against Streptococcus mutans, S. mitis, S. sanguinis, S. sobrinus, S. salivarius, Mycobacterium tuberculosis, M. avium and M. kansasii. EL-EO, ES-EO and α-bisabolol exhibited high leishmanicidal activity against promastigote forms of Leishmania amazonensis; IC50 values were 9.22 µg/mL, 6.00 µg/mL and 3.12 µg/mL, respectively. The 50% cytotoxic concentrations (CC50) of EL-EO, ES-EO and α-bisabolol against mouse peritoneal macrophages were 24.65 µg/mL, 8.87 µg/mL and 1021.00 µg/mL, respectively. These results suggest that EOs from E. erythropappus seem to be very promising for the development of new bactericidal and leishmanicidal agents.

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“…Regarding the action against T. cruzi trypomastigotes, the root EO was the most active (IC50: 70 μg/mL; SI = 3.1). The major compounds identified in this EO were modheph-2-ene (8.69%), agurjunene (9.61%), trans-caryophyllene (10.42%), β-isocomene (10.26%), and α-isocomene (15.41%) (Martins et al, 2015). Similarly, Moreira et al (2017) studied the effect of the EO from leaves of Vernonia polyanthes Less.…”

Section: Compounds From Vernonia Plants Are Active Against Trypanosommentioning

confidence: 93%

Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease

et al. 2019

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Leishmaniasis and Chagas disease cause great impact on social and economic aspects of people living in developing countries. The treatments for these diseases are based on the same regimen for over 40 years, thus, there is an urgent need for the development of new drugs. In this scenario, Asteraceae plants (a family widely used in folk medicine worldwide) are emerging as an interesting source for new trypanocidal and leishmanicidal compounds. Herein, we provide a non-exhaustive review about the activity of plant-derived products from Asteraceae with inhibitory action toward Leishmania spp. and T. cruzi . Special attention was given to those studies aiming the isolation (or identification) of the bioactive compounds. Ferulic acid, rosmarinic acid, and ursolic acid ( Baccharis uncinella DC.) were efficient to treat experimental leishmaniasis; while deoxymikanolide ( Mikania micrantha ) and (+)-15-hydroxy-labd-7-en-17-al ( Aristeguietia glutinosa Lam.) showed in vivo anti- T. cruzi action. It is also important to highlight that several plant-derived products (compounds, essential oils) from Artemisia plants have shown high inhibitory potential against Leishmania spp., such as artemisinin and its derivatives. In summary, these compounds may help the development of new effective agents against these neglected diseases.

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Chemical Composition, Antimicrobial and Antiprotozoal Activity of Essential Oils FromVernonia brasiliana(Less) Druce (Asteraceae)

Cited by 11 publications

References 12 publications

Effect of essential oils on Leishmania amazonensis: a systematic review

Effect of essential oils on Leishmania amazonensis: a systematic review

In vitro evaluation of anticaries, antimycobacterial, antileishmanial and cytotoxic activities of essential oils from Eremanthus erythropappus and of α-bisabolol, their major sesquiterpene

Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease

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