Chemical Composition, Antifungal and Insecticidal Activities of the Essential Oils from Tunisian Clinopodium nepeta subsp. nepeta and Clinopodium nepeta subsp. glandulosum

Debbabi, Haïfa; Mokni, Ridha El; Chaieb, Ikbal; Nardoni, Simona; Maggi, Filippo; Caprioli, Giovanni; Hammami, Saoussen

doi:10.3390/molecules25092137

Cited by 23 publications

(26 citation statements)

References 51 publications

(61 reference statements)

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“…Calamintha nepeta exhibited a moderate antifungal activity, while L. angustifolia , and R. officinalis had a weak effectiveness, varying among the different fungal isolates. Accordingly, Clinopodium (Calamintha) nepeta was recently found to be moderately active against M. canis and M. gypseum , but the EO obtained from a strain of subspecies glandulosum rich in piperitenone oxyde (39.3%) revealed an unexpected effectiveness against T. mentagrophytes [ 96 ], while all the dermatophytes were shown to be very sensitive to Thymus numidicus [ 97 ]. The poor antidermatophytic activity of R. officinalis (mostly containing alfa pinene, 1.8 cineol, and camphor) was confirmed by other authors [ 98 , 99 , 100 ].…”

Section: Fungal Infectionsmentioning

confidence: 99%

“…C. albicans was also checked with EOs obtained from Artemisia judaica and from Tagetes lucida , which did not yield any inhibiting effect, while a moderate activity was showed by Artemisia dracunculus [ 187 ]. C. nepeta was effective [ 96 ], and a very striking antifungal activity was showed by T. numidicus [ 97 ]. Ksouri et al [ 188 ] successfully checked several bovine clinical isolates cultured from mastitis, with Origanum floribundum and Thymus ciliatus.…”

Section: Fungal Infectionsmentioning

confidence: 99%

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Use of Essential Oils in Veterinary Medicine to Combat Bacterial and Fungal Infections

Ebani

Mancianti

2020

Veterinary Sciences

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Essential oils (EOs) are secondary metabolites of plants employed in folk medicine for a long time thanks to their multiple properties. In the last years, their use has been introduced in veterinary medicine, too. The study of the antibacterial properties of EOs is of increasing interest, because therapies with alternative drugs are welcome to combat infections caused by antibiotic-resistant strains. Other issues could be resolved by EOs employment, such as the presence of antibiotic residues in food of animal origin and in environment. Although the in vitro antimicrobial activity of EOs has been frequently demonstrated in studies carried out on bacterial and fungal strains of different origins, there is a lack of information about their effectiveness in treating infections in animals. The scientific literature reports some studies about in vitro EOs’ activity against animal clinical bacterial and fungal isolates, but in vivo studies are very scanty. The use of EOs in therapy of companion and farm animals should follow careful studies on the toxicity of these natural products in relation to animal species and route of administration. Moreover, considering the different behavior of EOs in relation to both species and strain pathogen, before starting a therapy, an aromatogram should be executed to choose the oil with the best antimicrobial activity.

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Section: Fungal Infectionsmentioning

confidence: 99%

Section: Fungal Infectionsmentioning

confidence: 99%

Use of Essential Oils in Veterinary Medicine to Combat Bacterial and Fungal Infections

Ebani

Mancianti

2020

Veterinary Sciences

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“…nepeta and subsp. glandulosum were found to have antifungal and insecticidal activity (Debbabi et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Seed germination, micropropagation from adult and juvenile origin explants and address of hyperhydricity of the Cretan endemic herb Calamintha cretica

Vlachou

Papafotiou

Bertsouklis

2020

Not Bot Horti Agrobo

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The optimum range of temperature for germination (96-100%) of Calamintha cretica, an herb with potential pharmaceutical and horticultural uses, was 15 to 20 °C, with 10 and 30 °C cardinal temperatures. Storage up to one year did not affect germination. The effect of zeatin (ZEA), 6-benzyladenine (BA), kinetin, and 6-γ-γ-(dimethylallylamino)-purine added in MS medium at concentrations from 0.0 to 8.0 mg L-1 was tested for shoot proliferation of both adult- and seedling-origin nodal explants at first- and sub-culture. Both explant types responded similarly during in vitro culture. At cytokinin concentrations up to 1 mg L-1 explant response was high (over 85%) but shoot number per explant was low (1.2-2.2). Increasing cytokinin from 2.0 to 8.0 mg L-1 resulted to an analogous decrease of explant response and shoot length, and an increase of shoot number, particularly when ZEA or BA was used (5.0-6.6 shoots per explant, 0.5-1.0 cm long) with simultaneous though increase of hyperhydricity (up to 50%). The addition of 0.1 mg L-1 naphthaleneacetic acid into the 8.0 mg L-1 BA medium almost eliminated hyperhydricity and increased explant response, while the increase of agar concentration from 8.0 to 12.0 g L-1 eliminated hyperhidricity and induced the highest shoot proliferation (93-95% explant response, 11.2-12.3 shoots per explant, 0.8-1.0 cm long). Microshoots and microshoot clusters rooted (88-96%) on half-strength MS medium either hormone free or supplemented with 1 to 4 mg L-1 indole-3-butyric acid. Plantlets survived at 80% to 100% after ex vitro acclimatization in peat: perlite 1:1 (v/v).

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“…Pulegone, isopulegone, piperitone, piperitenone, piperitenone oxide, menthone, isomenthone and menthol are the main constituents. 1,8-Cineole, menthofuran, carvacrol, thymol, linalool and their derivatives can also seldom be found [ 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. The second group is decidedly less common, and includes species like Clinopodium umbrosum (M.Bieb.)…”

Section: Discussionmentioning

confidence: 99%

A Novel Chemical Profile of a Selective In Vitro Cholinergic Essential Oil from Clinopodium taxifolium (Kunth) Govaerts (Lamiaceae), a Native Andean Species of Ecuador

et al. 2020

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A novel chemical profile essential oil, distilled from the aerial parts of Clinopodium taxifolium (Kunth) Govaerts (Lamiaceae), was analysed by Gas Chromatography-Mass Spectrometry (GC-MS, qualitative analysis) and Gas Chromatography with Flame Ionization Detector (GC-FID, quantitative analysis), with both polar and non-polar stationary phase columns. The chemical composition mostly consisted of sesquiterpenes and sesquiterpenoids (>70%), the main ones being (E)-β-caryophyllene (17.8%), α-copaene (10.5%), β-bourbonene (9.9%), δ-cadinene (6.6%), cis-cadina-1(6),4-diene (6.4%) and germacrene D (4.9%), with the non-polar column. The essential oil was then submitted to enantioselective GC analysis, with a diethyl-tert-butyldimethylsilyl-β-cyclodextrin diluted in PS-086 chiral selector, resulting in the following enantiomeric excesses for the chiral components: (1R,5S)-(−)-α-thujene (67.8%), (1R,5R)-(+)-α-pinene (85.5%), (1S,5S)-(−)-β-pinene (90.0%), (1S,5S)-(−)-sabinene (12.3%), (S)-(−)-limonene (88.1%), (S)-(+)-linalool (32.7%), (R)-(−)-terpinen-4-ol (9.3%), (S)-(−)-α-terpineol (71.2%) and (S)-(−)-germacrene D (89.0%). The inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) of C. taxifolium essential oil was then tested, resulting in selective activity against BChE with an IC50 value of 31.3 ± 3.0 μg/mL (positive control: donepezil, IC50 = 3.6 μg/mL).

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Chemical Composition, Antifungal and Insecticidal Activities of the Essential Oils from Tunisian Clinopodium nepeta subsp. nepeta and Clinopodium nepeta subsp. glandulosum

Cited by 23 publications

References 51 publications

Use of Essential Oils in Veterinary Medicine to Combat Bacterial and Fungal Infections

Use of Essential Oils in Veterinary Medicine to Combat Bacterial and Fungal Infections

Seed germination, micropropagation from adult and juvenile origin explants and address of hyperhydricity of the Cretan endemic herb Calamintha cretica

A Novel Chemical Profile of a Selective In Vitro Cholinergic Essential Oil from Clinopodium taxifolium (Kunth) Govaerts (Lamiaceae), a Native Andean Species of Ecuador

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