Chemical Composition and Future Perspectives of Essential Oil Obtained from a Wild Population of Stachys germanica L. Distributed in the Balkan Mountains in Bulgaria

Abstract

Stachys germanica L. (Lamiaceae) is a plant associated with a rich history in the traditional medicine of Iran, Turkey, and Serbia. However, researchers have not fully investigated the pharmacological potential of the herb, and scientific data on this plant species are limited. The aim of the current study was to evaluate the chemical composition of the essential oil (EO) obtained from the aerial parts of S. germanica L. growing wild in Bulgaria and to perform a comparative analysis of the chemical composition of EOs obtained from the same plant species from other geographical regions. For the evaluation of the chemical profile of the isolated EO, gas chromatographic analysis with mass spectrometry was performed. The most abundant terpene class was oxygenated monoterpenes, which accounted for 59.30% of the total EO composition. The bicyclic monoterpene camphor, as a compound of this class, was identified as the major constituent in the EO, accounting for 52.96% of the total oil composition. The chemical profile of Bulgarian EO is quite different compared to that of EOs from other regions. It is the only one to contain more than 50% camphor. In addition, EO contains significant amounts of the diterpene geranyl p-cymene (10.49%). This is the first study describing the chemical composition of EO from Bulgarian Stachys germanica L., and our results reveal some future perspectives for the evaluation of the biological activity of EO from the studied plant species as a new therapeutic agent or natural remedy targeting different medical conditions. The EO has a promising potential to be used as a biopesticide and repellent as well, an environmentally friendly and safer alternative to standard pesticides.

Metabolic Composition of Methanolic Extract of the Balkan Endemic Species Micromeria frivaldszkyana (Degen) Velen and Its Anti-Inflammatory Effect on Male Wistar Rats

“…Currently, the only data available in the scientific literature regarding the biological effects of M. frivaldszkyana extracts are reports on the antimicrobial and antioxidant activities of the plant, accompanied with some information about its phytochemical metabolites [2,7]. Similar effects are reported for plants of the genus Stachys, which also belong to the Lamiaceae family [14]. No data on the toxicity of the methanolic plant extract or its effects on the inflammation processes were found.…”