Chemical composition and biological activities of essential oil from
            <i>Grewia bulot</i>
            leaves

Pham, Ty Viet; Ho, Duc Viet; Tuan Le, Anh; Duy Ngo, Y; Thanh Thi Dang, Nhan; Quoc Le, Thang; Nguyen, Bao Chi

doi:10.1080/14786419.2023.2275739

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…In a separate publication, the cytotoxic potential of G bulot leaf oil against KB, Hep-G2, MCF-7, and SK-LU-1 cell lines was elucidated, revealing IC 50 values ranging from 44.04 ± 1.47 to 74.20 ± 3.71 μg/mL. 21 Collectively, these findings underscore the substantial promise of biphenyl-3,3 ′ ,4,4 ′ -tetrol ( 9) from the G bulot plant, suggesting its potential as a lead compound for anticancer applications. This contributes meaningfully to the expanding database on medicinal plants and their pharmacological attributes.…”

Section: Resultsmentioning

confidence: 99%

“…15,19,20 Previously, we have disseminated findings regarding the volatile compounds and the anti-inflammatory, antioxidant, and cytotoxic activities of extracts and oils derived from the leaves of G bulot. 21,22 In the present study, our research wishes to report chromatographic isolation, and structural elucidation for the isolates from G bulot leaves, and subsequently evaluate their cytotoxic potentials against several cancer cell lines.…”

Section: Introductionmentioning

confidence: 99%

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Chemical Constituents From the Leaves of Grewia bulot Gagn. and Their Cytotoxic Activity

Pham,

Ho,

Ngo

et al. 2024

Natural Product Communications

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Objective: The ultimate objective of this study was to isolate bioactive compounds from Grewia bulot Gagn. leaves and evaluate their cytotoxicity against a panel of human cancer cell lines. Methods: Compounds were isolated by column chromatography, whereas their chemical structures were elucidated by NMR spectroscopic data, and literature comparison. The cytotoxic activity of the isolated compounds was assessed using SRB assay against 4 cancer cell lines, including MCF-7 (human breast carcinoma), Hep-G2 (human hepatocellular carcinoma), KB (human carcinoma in the mouth), and SK-LU-1 (human lung carcinoma). Results: From the n-hexane extract, 4 compounds were isolated and identified as taraxerol (1), 3-( E)-coumaroyltaraxerol (2), 3-( Z)-coumaroyltaraxerol (3), and lupeol (4). Additionally, 6 compounds were isolated from the ethyl acetate extract and identified as daucosterol (5), trans-tiliroside (6), inugalactolipid A (7), (3 S,5 R,6 S,7 E,9 R)-7-megastigmene-3,6,9-triol (8), biphenyl-3,3′,4,4′-tetrol (9), and smiglabrone B (10). Among these isolates, only compound 9 exhibited moderate cytotoxic activity against all tested cancer cell lines with the IC50 values ranging from 31.67 to 63.15 µM. Conclusion: All these compounds have been detected from G bulot for the first time, biphenyl-3,3′,4,4′-tetrol (9) emerged as a promising candidate for cancer drug development. This study contributes to the growing body of knowledge regarding natural compounds with anticancer properties.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical Constituents From the Leaves of Grewia bulot Gagn. and Their Cytotoxic Activity

Pham,

Ho,

Ngo

et al. 2024

Natural Product Communications

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“…The cytotoxicity of the EO from P. leptostachya leaf was assessed using a sulforhodamine B assay on the SK-LU-1 cell line. Our earlier study described the detailed protocols for these experiments, focusing on cytotoxicity [ 44 ].…”

Section: Methodsmentioning

confidence: 99%

Essential Oil from Vietnamese Peperomia leptostachya Hook. & Arn. (Piperaceae): Chemical Composition, Antioxidant, Anti-Inflammatory, Cytotoxic Activities, and In Silico Analysis

Nguyen,

Pham,

et al. 2024

Molecules

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This study is the first to investigate the chemical composition and antioxidant, anti-inflammatory, and cytotoxic activities of Peperomia leptostachya leaf oil. A yellow oil was obtained through hydro-distillation, with a yield of 0.1% (w/w). The GC-MS analysis revealed 66 compounds, constituting 99.6% of the oil. Sesquiterpene hydrocarbons predominated (70.4%), followed by monoterpene hydrocarbons (13.2%), oxygenated sesquiterpenes (12.4%), non-terpenic compounds (2.0%), and oxygenated monoterpenes (1.6%). Major constituents included germacrene D (25.1%), (E)-caryophyllene (17.4%), bicyclogermacrene (6.6%), α-pinene (6.2%), and β-pinene (4.7%). The assessment of antioxidant capacity via 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay yielded a weak effect, with an IC50 value > 100 µg/mL. The inhibition of lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells was quantified using the MTT assay, showing an IC50 value of 15.15 ± 0.68 µg/mL. Furthermore, cytotoxic effects on SK-LU-1 cell line growth were evaluated using the sulforhodamine B assay, resulting in an IC50 value of 37.45 ± 2.43 μg/mL. The anti-inflammatory activity was notable among the analyzed bioactivities of this oil. By employing a computational model, the predominant secondary metabolites in the essential oil were selected as candidates for interaction analysis with cyclooxygenase-2, an enzyme implicated in the inflammatory response. Our findings suggest that P. leptostachya leaf oil could serve as a potential source of natural compounds with prospective therapeutic effects in treating inflammatory conditions.

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Assessment of ethanolic extract of Dittrichia viscosa from Kardoussa Douar region of Taza in Morocco as antioxidant and green inhibitor for carbon steel corrosion in acidic medium

Chahboun,

Timoudan,

Belhoussaine

et al. 2024

International Journal of Electrochemical Science

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Chemical composition and biological activities of essential oil from Grewia bulot leaves

Cited by 4 publications

References 30 publications

Chemical Constituents From the Leaves of Grewia bulot Gagn. and Their Cytotoxic Activity

Chemical Constituents From the Leaves of Grewia bulot Gagn. and Their Cytotoxic Activity

Essential Oil from Vietnamese Peperomia leptostachya Hook. & Arn. (Piperaceae): Chemical Composition, Antioxidant, Anti-Inflammatory, Cytotoxic Activities, and In Silico Analysis

Assessment of ethanolic extract of Dittrichia viscosa from Kardoussa Douar region of Taza in Morocco as antioxidant and green inhibitor for carbon steel corrosion in acidic medium

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