Chemical composition and antiproliferative, antioxidant and trypanocidal activities of the fruits from Campomanesia xanthocarpa (Mart.) O. Berg (Myrtaceae)

Abstract

Chemical investigation of the extracts of the fruits fromCampomanesia xanthocarpa resulted in the isolation of six known compounds identified by NMR and comparison with literature data (2',4'-dihydroxy-5'methyl-6'-methoxychalcone (1), 2',4'-dihydroxy-3',5'-dimethyl-6'methoxychalcone (2), 2'-hydroxy-3'-methyl-4',6'-dimethoxychalcone (3), 2',6'dihydroxy-3'-methyl-4'-methoxychalcone (4), 5-hydroxy-7-methoxy-8methylflavanone (5) and 7-hydroxy-5-methoxy-6-methylflavanone ( 6)). The considerable antioxidant capacity of the extracts was demonstrated by ORAC-FL and DPPH tests. The antiproliferative assay of the extracts and 5 was done in vitro, against many different cancer cell lines besides a healthy one. The extracts presented low cytotoxicity and the substance demonstrated promising results against all of the cancer cell lines tested, with IC 50 values ranging from 4.75 to 45.81 µmol L -1 . The in vitro trypanocidal activity was evaluated against the epimastigote form of the Y strain of Trypanosoma cruzi and an improvement in

Effect of Supplementation with Hydroethanolic Extract of Campomanesia xanthocarpa (Berg.) Leaves and Two Isolated Substances from the Extract on Metabolic Parameters of Mice Fed a High-Fat Diet

“…Two important baseline studies observed that Ext and S1 (chalcone) were used as anti-inflammatory agents in carrageenan-induced paw edema in rodents [10] and that S2 (flavanone) displayed trypanocidal activity against Trypanosoma cruzi [25]. At the same time, toxic effects, such as alterations in food consumption, water intake, behavior and the weight of organs (heart, lung, spleen, liver and kidney) from Ext were not observed [10].…”

“…Even though Ext has presented phenols, flavonoids and tannins that were quantified following specific methodologies in the baseline study [10], our results revealed that Ext did not improve most metabolic and histological parameters and obesity features in HFD-fed mice. Despite not evaluating the mechanism of action involved in impairing metabolic responses found by Ext, it is important to emphasize that, depending on the experimental model (rodents or human clinical trials), different metabolic responses may be observed [28,29], and the different stimuli to which these models are subjected must be considered, such as different types of extracts, as observed from C. xanthocarpa leaf aqueous extracts [16,17,25], time and dose of treatment, diet, genetic factors, age, and gender, which may influence metabolic responses [30][31][32][33].…”

“…The chalcone was identified as 2 ,4 -dihydroxy-3 ,5 -dimethyl-6 -methoxychalcone (1) [10] and the flavanone was identified as 5-hydroxy-7-methoxy-8-methylflavanone (2) [25].…”

Atividade Antioxidante De Óleos Essencias Da Família Myrtaceae Pelo Método De Dpph: Uma Revisão De Literatura

“…Posteriormente, a solução é incubada por 20 a 30 minutos em temperatura ambiente e na ausência de luz e, em seguida, realiza-se a leitura por espectrofotometria (517 nm). Myrtaceae é uma das maiores famílias conhecida por suas espécies apresentarem potencial medicinal promissor e vários estudos relatam propriedades antioxidante desta família (Takao, Imatomi & Gualtieri, 2015;Scur et al, 2016;Musthafa et al, 2017;Carneiro et al, 2017;Donado-Pestana et al, 2018;Salmazzo et al, 2019). A composição química de OEs da família Myrtaceae é descrita por apresentar percentual significativo de terpenos, compostos que estão envolvidos no aroma e efeitos farmacológicos (Obiloma et al 2019).…”

Photosynthetic Performance, Nutrition and Growth of Campomanesia xanthocarpa O. Berg. in Chicken Manure Substrate and Liming

“…It has nutritional importance because its fruits have high levels of vitamins, fiber (Vallilo et al, 2008) and pectins (Barbieri et al, 2019). As medicinal it has anti-inflammatory (Klafke et al, 2016), antimicrobial, antioxidant (Capeletto et al, 2016), antiproliferative, trypanocidal (Salmazzo et al, 2019), activity and inhibitory effect on platelet aggregation (Otero et al, 2017).…”