Chemical composition and antioxidant activity of the endemic Crataegus microphylla Koch subsp. malyana K. I. Chr. &amp; Janjić from Bosnia

Čopra-Janićijević, Amira; Čulum, Dušan; Vidić, Danijela; Tahirović, A.; Klepo, Lejla; Bašić, Neđad

doi:10.1016/j.indcrop.2018.01.016

Cited by 20 publications

(13 citation statements)

References 27 publications

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“…Polyphenols, a large category of secondary plant metabolites, have been widely studied for their biological functions in combating chronic disease due to their high antioxidant activities [ 3 , 4 , 5 ]. In this context, fruits, vegetables, and plants that are rich in polyphenols such as Ginkgo biloba , Crataegus pinnatifida , and Cyclocarya paliurus , are receiving increasing attention from pharmacological researchers and nutritionists [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Geographic Variation in the Chemical Composition and Antioxidant Properties of Phenolic Compounds from Cyclocarya paliurus (Batal) Iljinskaja Leaves

et al. 2018

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Cyclocarya paliurus has been widely used as an ingredient in functional foods in China. However, the antioxidant properties of phenolic compounds and the effect of the plant origin remain unclear. The present study evaluated the geographical variation of this plant in term of its phenolic composition and antioxidant activities based on leaf materials collected from five regions. high-performance liquid chromatography (HPLC) analysis showed that there are three major components, quercetin-3-O-glucuronide, kaempferol-3-O-glucuronide, and kaempferol-3-O-rhamnoside, and their contents varied significantly among sampling locations. The investigated phenolic compounds showed substantial antioxidant activities, both in vitro and in vivo, with the highest capacity observed from Wufeng and Jinzhongshan. Correlation analysis revealed that quercetin and kaempferol glycosides might be responsible for the antioxidant activities. Our results indicate the importance of geographic origin, with sunny hours and temperature as the main drivers affecting the accumulation of C. paliurus phenolics and their antioxidant properties.

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Section: Introductionmentioning

confidence: 99%

Geographic Variation in the Chemical Composition and Antioxidant Properties of Phenolic Compounds from Cyclocarya paliurus (Batal) Iljinskaja Leaves

et al. 2018

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“…Methanol–acetonitrile–water–glacial acetic acid (20:10:70:1) was used as the mobile phase. The injected volume was 20 µL, 0.02 Hz filter, range of 50 nA, and the column was thermostatted at a temperature of 25 °C [ 30 ]. The results were expressed per gram of dry weight (DW) of plant material.…”

Section: Methodsmentioning

confidence: 99%

HPLC-ED Analysis of Phenolic Compounds in Three Bosnian Crataegus Species

Čulum

Čopra-Janićijević

Vidić

et al. 2018

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The aim of this work was the qualitative and quantitative determination of selected phenolic compounds in three Crataegus species grown in Bosnia. Crataegus plants are consumed for medicinal purposes and as foodstuff in the form of canned fruit, jam, jelly, tea, and wine. Two samples of plant material, dry leaves with flowers, and berries of three Crataegus species—Crataegus rhipidophylla Gand., Crataegus x subsphaericea Gand., and Crataegus x macrocarpa Hegetschw.—were analyzed. Twelve ethanolic extracts were isolated from the selected plant material using Soxhlet and ultrasound extraction, respectively. Soxhlet extraction proved to be more effective than ultrasound extraction. A simple and sensitive method, high-performance liquid chromatography with electrochemical detection, HPLC-ED, was used for the simultaneous determination of phenolic acids and flavonoids in Crataegus species. The content of gallic acid in the extracts ranged from 0.001 to 0.082 mg/g dry weight (DW), chlorogenic acid from 0.19 to 8.70 mg/g DW, and rutin from 0.03 to 13.49 mg/g DW. Two flavonoids, vitexin and hyperoside, commonly found in chemotaxonomic investigations of Crataegus species, were not detected in the examined extracts. In general, leaves with flowers samples are richer in gallic acid and rutin, whereas the berries samples are richer in chlorogenic acid. Distinct similarities were found in the relative distribution of gallic acid among the three species. Extracts of C. x macrocarpa had the highest content of all detected compounds, while significant differences were found in rutin content, depending on the plant organ. To the best of our knowledge, this is the first study reporting content of phenolic compounds in Crataegus rhipidophylla Gand., Crataegus x subsphaericea, and Crataegus x macrocarpa from Bosnia.

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“…17 Total flavonoid content The flavonoid contents of leaf, bark and twig were determined using a slightly modified method. 18 The sample and 2%AlCl3 (1:1) were added to 96-well plates. The solution was left to stand at room temperature for 20 min.…”

Section: Dipterocarpol Contentmentioning

confidence: 99%

Inhibitory Effect of Leaf, Bark and Twig of Dipterocarpus alatus on the Inflammation Mediators, Nitric Oxide, PGE2, IL-1? and TNF-? in Macrophage RAW 264.7

2021

TJNPR

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Dipterocarpus alatus has been used in traditional medicine to treat leprosy and gonorrhoea and for relief of pain but there are limited studies investigating the mechanisms of this activity. In this work, we screened D. alatus leaf, bark and twig extracts for anti-inflammatory activity using lipopolysaccharide (LPS) stimulated RAW 264.7 cells and determined their effects on inflammatory mediators and cytokines. D. alatus extracts were tested for cytotoxicity and effects on NO, PGE2, IL-1β and TNF-α production in LPS-stimulated RAW 264.7 macrophages using Griess reaction and ELISA test kits. All extracts were non-toxic to RAW 264.7 cells at a concentration of 100 µg/mL. Extracts from all tested parts of D. alatus reduced levels of NO, PGE2, and IL-1β but did not affect TNF-α in LPS-stimulated RAW 264.7 cells. Thus, D. alatus extracts show specific anti-inflammatory activity with good potential as a treatment for inflammatory diseases.

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Chemical composition and antioxidant activity of the endemic Crataegus microphylla Koch subsp. malyana K. I. Chr. & Janjić from Bosnia

Cited by 20 publications

References 27 publications

Geographic Variation in the Chemical Composition and Antioxidant Properties of Phenolic Compounds from Cyclocarya paliurus (Batal) Iljinskaja Leaves

Geographic Variation in the Chemical Composition and Antioxidant Properties of Phenolic Compounds from Cyclocarya paliurus (Batal) Iljinskaja Leaves

HPLC-ED Analysis of Phenolic Compounds in Three Bosnian Crataegus Species

Inhibitory Effect of Leaf, Bark and Twig of Dipterocarpus alatus on the Inflammation Mediators, Nitric Oxide, PGE2, IL-1? and TNF-? in Macrophage RAW 264.7

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