“…The less specific BChE has recently been a focus of research, because BChE concentration stays the same, or is even up-regulated, while AChE is dramatically down-regulated in the brains of patients suffering from AD 36 . It was previously reported that essential oils rich in terpenes exhibit a strong inhibitory activity against both enzymes 35,37,38 . Among the Pinus essential oil components, five compounds, namely β-phellandrene, terpinolene, terpinen-4-ol, linalyl acetate, and trans-caryophyllene, were tested for the first time in this study to evaluate their potential activity ( Table 2).…”