Chemical and technological evaluation of the Phyllanthus niruri aerial parts as a function of cultivation and harvesting conditions

Couto, Angélica Garcia; Kunzler, Marli Liani; Spaniol, Bárbara; Magalhães, Pedro Melillo de; Ortega, George González; Petrovick, Pedro Ros

doi:10.1590/s0102-695x2013005000002

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…The calibration curve of quercetin and gallic acid showed good linearity (r2 = 0.998) for the concentration range from 0.005 to 0.5 g/ml. The analysis time using UPLC method in this work is about 20 minutes, which is faster than other reported methods such as 32 minutes [12], 40 minutes [10] and 45 minutes [13].…”

Section: Uplc Quantification Of Gallic Acid and Quercetinmentioning

confidence: 71%

Optimisation of Gallic Acid and Quercetin Extraction from Phyllanthus Niruri

Nguang¹,

Yeong²,

Pang³

et al. 2018

IJET

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This paper presents an optimization study of gallic acid and queretin extraction from Phyllanthis niruri by using response surface methodology. Gallic acid and quercetin was extracted with the aid of sonication and the polyphenols content was analyzed using Ultra Performance Liquid Chromatography (UPLC). The effect of extraction time, amplitude and ethanol concentration on the yield of gallic acid and quercetin were investigated. The optimum gallic acid yield (10.43 ± 0.28 mg GA/g DW) was found in ethanol concentration of 40.0%, extraction time of 15 minutes and amplitude of 86.85% after solving the regression equation. Meanwhile, the optimum condition to obtain the highest yield of quercetin (17.48 ± 0.21 mg Que/g DW) was found in ethanol concentration of 40.0%, extraction time of 15 minutes and amplitude of 75%. The findings in this work may serve as a useful guide to obtain highest extraction yield of gallic acid and quercetin from Phyllanthus niruri.

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Section: Uplc Quantification Of Gallic Acid and Quercetinmentioning

confidence: 71%

Optimisation of Gallic Acid and Quercetin Extraction from Phyllanthus Niruri

Nguang¹,

Yeong²,

Pang³

et al. 2018

IJET

View full text Add to dashboard Cite

show abstract

“…The technological development of research on pharmaceutical forms containing herbal materials has expanded over recent decades and contributed to innovation in the pharmaceutical sector (Bassani, González, Petrovick, 2005;Calixto, 2005;Rocha et al, 2008;Araújo-Júnior et al, 2013;Beringhs et al, 2013;Couto et al, 2013;Klein et al, 2013;Quintão et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Microemulsion based on Pterodon emarginatus oil and its anti-inflammatory potential

Pascoa

Diniz

Florentino

et al. 2015

Braz. J. Pharm. Sci.

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This article reports the development of a pharmaceutical product containing vegetable actives from a Brazilian medicinal plant. The possibility of forming a microemulsion using Pterodon emarginatus ("sucupira") oil was evaluated and the anti-inflammatory potential of this microemulsion was also examined. A formulation was developed using P. emarginatus oil, a mixture of ethoxylated Castor Oil (Ultramone ® R-540/propylene glycol 2:1) (surfactant/cosurfactant) and distilled water at a ratio of 10:15:75, respectively. The microemulsion which was selected was then subjected to the preliminary stability test and analyzed in terms of average diameter of droplets, pH, zeta potential, and polydispersity index, on the 1 st , 7 th , 15 th , and 30 th days after preparation and stored at different temperatures (5 ± 2 °C, 25 ± 2 °C, and 40 ± 2 °C). The anti-inflammatory in vivo activity of both oil and formulation were evaluated, using the experimental model of croton oil-induced ear edema. The preliminary stability test showed that the microemulsion stored at 5 and 25 °C retained its original features throughout the 30-day period. The anti-inflammatory potential of both oil and formulation was shown to be statistically significant (p < 0.001), when compared to the control group, however, the microemulsion proved to be more effective (p < 0.05) than the oil when applied directly to the ear. Descrevemos o desenvolvimento de um produto farmacêutico contendo ativo vegetal baseado em uma planta medicinal brasileira. Foi avaliada a habilidade de formação de uma microemulsão à base do óleo de Pterodon emarginatus (sucupira) e seu potential anti-inflamatório. Uma formulação foi desenvolvida utilizando o óleo de P. emarginatus, mistura de óleo de mamona etoxilado (Ultramona ® R-540)/propilenoglicol (2:1) (tensoativo/cotensoativo) e água destilada, na proporção de 10:15:75, respectivamente. A microemulsão selecionada foi submetida ao teste preliminar de estabilidade e foi analisada quanto ao diâmetro médio das gotículas, pH, potential zeta e índice de polidispersão, no 1º, 7º, 15º e 30º dias após o preparo e foram estocadas em diferentes temperaturas (5±2 °C, 25±2 °C e 40±2 °C). Avaliaram-se a atividade anti-inflamatória in vivo do óleo de sucupira e da formulação, usando o modelo experimental do edema de orelha induzido pelo óleo de cróton. No teste preliminar de estabilidade observou-se que a formulação estocada a 5 °C e a 25 °C mantiveram suas características originais durante 30 dias. O potencial anti-inflamatório de ambos, óleo de sucupira e formulação foi estatisticamente significativo (p <0.001), quando comparado ao controle, porém a microemulsão foi mais eficiente (p <0.05) que o óleo aplicado diretamente nas orelhas dos animais. Unitermos:Pterodon emarginatus/pharmacognosy. Pterodon emarginatus/óleo/atividade antiinflamatória. Plantas medicinais. Microemulsão. Fitoterápico. Tecnologia farmacêutica.

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Chemical and technological evaluation of the Phyllanthus niruri aerial parts as a function of cultivation and harvesting conditions

Cited by 3 publications

References 6 publications

Optimisation of Gallic Acid and Quercetin Extraction from Phyllanthus Niruri

Optimisation of Gallic Acid and Quercetin Extraction from Phyllanthus Niruri

Microemulsion based on Pterodon emarginatus oil and its anti-inflammatory potential

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