Charge transfer complex of some nervous and brain drugs – Part 1: Synthesis, spectroscopic, analytical and biological studies on the reaction between haloperidol antipsychotic drugs with π-acceptors

Synthesis and spectroscopic characterization of trazodone charge transfer complexes with different types of π-acceptors

“…The maximum differential thermal analysis DTG max of the first decomposition steps located within the temperature range of 44-367°C, which have a weight losses of approximately 49. 23 Thermodynamic data. Two different common methods were employed to evaluate the kinetic thermodynamic parameters: the Coats-Redfern method [37] and the Horowitz-Metzger method [38].…”

“…Charge-transfer complexes of organic species are intensively studied because of their special type of interaction, which is accompanied by transfer of an electron from the donor to the acceptor [15,16]. The π-acceptors have numerous applications as analytical reagents, for example they have been used for the spectrophotometric determination of many drugs in pharmaceutical formulations [17][18][19][20][21][22][23]. In continuation of our studies on charge transfer complexes of dif-DOI: 10 ferent drug types [18,19,[21][22][23], this paper discloses simple, fast, and accurate spectrophotometric method for the determination of trazodone using some π-acceptors.…”

Chemistry of drug interactions: Characterization of charge-transfer complexes of Guaifenesin with various acceptors using spectroscopic and thermal methods

“…The Horowitz-Metzger equation [27] can be represented using Eq. (11). θ = T -T s , w γ = w α -w, w α is the mass loss at the completion of the reaction, and w is the mass loss at time t. The plot of log [log (w α /w γ )] vs. θ was constructed and was observed to be linear, and E * was calculated from its slope.…”

“…It is termed an expectorant since it is believed to alleviate cough discomfort by increasing sputum volume and decreasing its viscosity (hydration hypothesis), thereby promoting effective cough. Based on the interesting results obtained for the complexation properties of drugs with acceptors, in this research, as a continuation of our work in this field [7][8][9][10][11][12][13][14][15][16][17][18][19], the interactions of guaifenesin with two types of acceptors (σ-and π-acceptors) were investigated. First, the CT complexes of GU with iodine, DDQ, CHL and PA acceptors were obtained.…”

Spectroscopic studies on the utility of charge transfer interactions for determination of phenytoin sodium

“…Also, protonation of the donor from acidic acceptors are general route for the formation of ion pair adducts [17][18][19]. The πacceptors have numerous applications as analytical reagents for ex., they have been used for the spectrophotometric determination of many drugs in pharmaceutical formulations [20][21][22][23][24][25][26]. To the best of our knowledge, no wide spectroscopic studies have been performed on the interactions between phenytoin sodium and different classes of π-acceptors.…”