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Cited by 14 publications
(34 citation statements)
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References 120 publications
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“…Compared to the VCD-Vehicle group, the VCD-E2 group had significantly fewer primordial follicles [F (1 , 16) = 6.10, p < 0.05] and fewer primary follicles [F (1 , 16) = 9.89, p < 0.01] (Figures 13A,B), an effect we have previously observed in follicle-depleted rats with tonic E2 treatment (Koebele et al, 2020a). Secondary follicles, antral follicles, and corpora lutea counts did not differ between VCD-Vehicle and VCD-E2 groups, although both groups exhibited substantial follicle decline, indicating successful VCD-induced follicular depletion.…”
Section: How Does Daily E2-only Treatment Affect Ovarian Follicle Profiles With Transitional Menopause?mentioning
confidence: 57%
See 1 more Smart Citation
“…Compared to the VCD-Vehicle group, the VCD-E2 group had significantly fewer primordial follicles [F (1 , 16) = 6.10, p < 0.05] and fewer primary follicles [F (1 , 16) = 9.89, p < 0.01] (Figures 13A,B), an effect we have previously observed in follicle-depleted rats with tonic E2 treatment (Koebele et al, 2020a). Secondary follicles, antral follicles, and corpora lutea counts did not differ between VCD-Vehicle and VCD-E2 groups, although both groups exhibited substantial follicle decline, indicating successful VCD-induced follicular depletion.…”
Section: How Does Daily E2-only Treatment Affect Ovarian Follicle Profiles With Transitional Menopause?mentioning
confidence: 57%
“…Based on prior data from our and other laboratories, normal estrous cyclicity is disrupted approximately 4 months after VCD injection administration, and vaginal cytology can be modified by a given hormone therapy regimen (Koebele et al, 2020a).…”
Section: Vaginal Cytologymentioning
confidence: 99%
“…As with all animal models some limitations associated with the model system should be mentioned. First, although well-established, 23 particularly in cognitive and cardiology research 24,110,111 and believed to be non-toxic/ovarian follicle specific, 24,112 the VCD menopause induction may introduce as yet unidentified off-target impacts. The timing of the VCD and cognitive assessment (ie, middle-aged animals) could have resulted in some sham animals being spontaneously acyclic.…”
Section: Discussionmentioning
confidence: 99%
“…Our laboratory has also systematically tested E2 HT in surgical (Ovx) and transitional (VCD) rodent menopause models, whereby strong working memory benefits were observed with E2 treatment following surgical menopause [70]. In contrast, in the transitional model of menopause, both learning benefits and retention deficits were observed with E2 treatment [54]. These divergent cognitive effects depending upon menopause history have also been observed with CEE.…”
Section: Use Of E2 or Conjugated Equine Estrogens As The Estrogenic Component In Hormone Therapymentioning
confidence: 97%
“…Furthermore, Daniel and colleagues performed an elegant series of experiments highlighting the importance of HT timing and duration, demonstrating that immediate, but not delayed, E2 treatment benefits attentional processes [47], and that transient E2 exposure in midlife can have long-lasting memory benefits and enhance hippocampal estrogen receptor expression, even after E2 treatment is discontinued in an Ovx model [48,49]. It is important to note that preclinical cognitive and neurobiological effects of estrogen are not always consistent, even when given in this critical window; menopause type, HT type and behavior testing account for some variations in outcomes [44,[50][51][52][53][54][55][56][57][58].…”
Section: Timing Of Hormone Therapy Relative To Menopause and Age: Insights From Preclinical Researchmentioning
confidence: 99%