Characterizing Multimorbidity from Type 2 Diabetes

Abstract

Patients with type 2 diabetes mellitus (T2DM) often live with and develop multiple co-occurring conditions, namely multimorbidity, with diffuse impacts on clinical care and patient quality of life. However, literature characterizing T2DM-related multimorbidity patterns is limited. This review summarizes the findings from the emerging literature characterizing and quantifying the association of T2DM with multimorbidity clusters. The authors’ findings reveal 3 dominant cluster types appearing in patients with T2DM-related multimorbidity, such as cardiometabolic precursor conditions, vascular conditions, and mental health conditions. The authors recommend that holistic patient care centers around early detection of other comorbidities and consideration of wider risk factors.

Multimorbidity Patterns among People with Type 2 Diabetes Mellitus: Findings from Lima, Peru

“…The use of cluster analysis allows a better characterization of multimorbidity patterns by identifying subsets of the T2DM population that may need different demands from the health system [ 7 ], but also it can provide an understanding of potential etiologies that are related to T2DM morbidity. In this line, T2DM cases with obesity may imply recent diagnosis which could require a different management (i.e., number and type of medications, number of control visits, etc.)…”

“…T2DM is a chronic condition which is often found with other chronic diseases even among younger subjects [ 7 , 8 ]. The presence of two or more chronic conditions in the same individual is known as multimorbidity, and the current evidence shows that multimorbidity is more common among people with T2DM, amongst whom the prevalence of multimorbidity may range between 30% to almost 90% [ 9 , 10 , 11 ].…”

Stationäre Patienten mit der Nebendiagnose Diabetes mellitus: klinische Relevanz

“…Bei Komorbiditäten wie Asthma bronchiale und COPD (chronisch-obstruktive Lungenerkrankung), Depression, anderen psychiatrischen Erkrankungen und Osteoarthritis/chronischem Rückenschmerzsyndrom [ 7 , 87 ] bestehen keine klaren pathophysiologischen oder therapeutischen Zusammenhänge mit dem Diabetes.…”

“…Die Konsequenzen der unterschiedlichen Komorbiditätscluster auf die medizinische Betreuung von Patienten mit Diabetes mellitus – Priorisierung von Erkrankungen bezüglich der Ressourcen für ihre Diagnostik und Therapie oder auch Synergismen in der Behandlung – sind Gegenstand wissenschaftlicher Forschung [ 7 ]. Im Falle einer stationären Aufnahme wegen konkordanter (insbesondere traditioneller) Begleiterkrankungen ist davon auszugehen, dass der Diabetes mellitus als sog.…”

Association of Prediabetes with the Risks of Adverse Health Outcomes and Complex Multimorbidity: An Observational Study

“…Patients with diabetes are at high risk of living with multiple co-occurring conditions, such as dyslipidemia, cardiovascular-related disease, microvascular complications, depression [3,4], as well as an increased risk for dementia. Similar to diabetes, prediabetes can also cause multiple systemic damage.…”