2020
DOI: 10.1093/rheumatology/keaa070
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Abstract: Objectives Infection exerts a major burden in ANCA-associated vasculitis (AAV), however, its precise extent and nature remains unclear. In this national study we aimed to longitudinally quantify, characterize and contextualize infection risk in AAV. Methods We conducted a multicentre matched cohort study of AAV. Complementary data on infections were retrieved via data linkage with the population-based Scottish microbiological… Show more

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Cited by 16 publications
(19 citation statements)
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“…Compared with the respective SI incidence rate late after diagnosis (4th year and beyond), the risk for SI during the 1st year was approximately 4 times higher. This temporal trend comes in agreement with older [ 3 , 9 ] and more recently published studies [ 6 , 10 ].…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Compared with the respective SI incidence rate late after diagnosis (4th year and beyond), the risk for SI during the 1st year was approximately 4 times higher. This temporal trend comes in agreement with older [ 3 , 9 ] and more recently published studies [ 6 , 10 ].…”
Section: Discussionsupporting
confidence: 92%
“…Despite the substantial progress in the AAV therapeutics with the introduction of monoclonal biologic therapies (rituximab-RTX) [ 4 , 5 ], the incidence of SI in AAV has remained relatively stable. Their rate is significantly higher compared to the age-matched general population [ 6 ] without decreasing trends in recent cohorts [ 7 ]. Although long-term extension studies from the initial randomized controlled trials (RCTs) have provided useful data regarding the incidence and risk factors for SI in these patients, real-world data for the different phases of AAV comparing SI in the biologic era are limited.…”
Section: Introductionmentioning
confidence: 99%
“…We could confirm that severe infections are very common in ANCA-GN patients 2,5 corroborating a recent multicentre retrospective study showing a higher incidence as compared to an age-and gender-matched population 2 In recent large trials (MEPEX and PEXIVAS trials) S7,S8 , infections represented a major risk factor for death in ANCA-GN patients. Our observation that kidney function at month 6 (and not at ANCA-GN diagnosis) is the major risk factor for late infection suggests that infection risk may decrease if kidney function improves following remission induction treatment.…”
Section: Temporal Trend Analysis Of Infection Risk Factorssupporting
confidence: 86%
“…Despite great improvement in anti-neutrophil cytoplasmic antibody (ANCA)−associated vasculitis (AAV) management, S1 morbidity and mortality of AAV patients remain significantly higher than in the general population. Indeed, 5-year mortality rate reaches 20% to 25%, 1 , 2 mainly due to kidney and lung involvement. S2 Causes of death have been widely analyzed, and have related to vasculitis activity, cardiovascular events, cancers, and infections 1 , 3 , S1 in a complex interplay of baseline comorbidities, vasculitis activity, and regimen toxicity.…”
mentioning
confidence: 99%
“…However, glucocorticoid use may be complicated by numerous side effects. In the short term, infection is the main treatmentrelated complication [8]. In the longer term, cardiovascular disease and osteoporosis are important morbidities [9].…”
Section: Take Down Policymentioning
confidence: 99%