2016
DOI: 10.18632/aging.101058
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Abstract: Multiple sclerosis is among the most serious inflammatory demyelinating diseases (IDD). Interleukin-23A (IL23A) regulates and coordinates the activities of immune cells by interacting with its receptor IL23R and plays key roles in the pathogenesis of immune inflammatory diseases. IDD, deemed to be a kind of autoimmune diseases, may involve IL23A in the pathogenesis. The aim of this work was to validate the hypothesized involvement of IL-23A and its receptor in IDD. We sequenced the IL-23A and IL-23R genes for … Show more

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Cited by 19 publications
(17 citation statements)
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References 40 publications
(42 reference statements)
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“…We were conducted the statistical analyses and Hardy-Weinberg equilibrium tests of the study participants using SPSS software (version 19.0) [43] and Plink (version 1.9) [44,45] . And as previously study showen, using the online software SNPSpD and Haploview software, we were calculated the experiment-wide significance threshold and the matrix of mpirwise linkage-disequilibrium (LD) correlation [46] .…”
Section: Discussionmentioning
confidence: 99%
“…We were conducted the statistical analyses and Hardy-Weinberg equilibrium tests of the study participants using SPSS software (version 19.0) [43] and Plink (version 1.9) [44,45] . And as previously study showen, using the online software SNPSpD and Haploview software, we were calculated the experiment-wide significance threshold and the matrix of mpirwise linkage-disequilibrium (LD) correlation [46] .…”
Section: Discussionmentioning
confidence: 99%
“…Overall OC genetics correlation analysis was also conducted. As previously reported, the statistical analyses and Hardy-Weinberg equilibrium tests of the patients and control populations were conducted [29,[32][33][34].…”
Section: Snp Genotyping and Statistical Analysismentioning
confidence: 99%
“…Considering that IL-23 cytokine has an important role in the atherosclerosis process, the gene that encodes this cytokine could be a candidate for genetic association studies. Genetic studies have associated the rs2066808, rs2371494, and rs11575248 polymorphisms in the IL-23A gene with susceptibility to multiple sclerosis 121 . Alternatively, the rs11171806 polymorphism in the IL-23A gene has been significantly associated with susceptibility to Graves' disease in Han Chinese 122 , but not in the northern Italian population 123 .…”
Section: Il-23a Genementioning
confidence: 99%