Characterization of tissue from the bone-polymethylmethacrylate interface in a rat experimental model. Demonstration of collagen-degrading activity and bone-resorbing potential.

Coe, M R; Fechner, R E; Jeffrey, J J; Balian, G; Whitehill, R

doi:10.2106/00004623-198971060-00011

Cited by 14 publications

(6 citation statements)

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“…Because of the relatively lower setting temperature (<65°C), the canals adjacent to the Sr‐HA cement can survive. In contrast, PMMA cement has a high curing temperature, which damages cell activity, leading to necrosis 4. Volkmann's canals, containing blood vessels, run perpendicular to the osteons.…”

Section: Discussionmentioning

confidence: 99%

“…Aseptic loosening, however, remains the most important long‐term complication. The causes of loosening have been reported to be: (1) intervention of fibrous tissue at the cement–bone interface;1–2 (2) adverse biological responses induced by various wear debris;3–4 (3) occurrence of micromovement at the cement–bone interface;5 and (4) insufficient fatigue strength of the PMMA bone cement itself 6…”

Section: Introductionmentioning

confidence: 99%

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Strontium‐containing hydroxyapatite (Sr‐HA) bioactive cement for primary hip replacement: An in vivo study

Chiu

et al. 2005

J Biomed Mater Res

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The purpose of this study was to evaluate the strontium-containing hydroxyapatite (Sr-HA) cement in primary hip replacement, using a rabbit model, and to investigate the histological findings at the cement-implant and bone-cement interfaces under weight-bearing conditions. Unilateral hip replacement was performed with Sr-HA cement or polymethylmethacrylate (PMMA) cement in rabbits and observations were made after 6 months. Good fixation between the Sr-HA cement and implant was observed. Osseointegration of the Sr-HA cement with cancellous bone was widespread. Many multinucleus cells covered the surface of the cement, and resorbed the superficial layer of the cement. By scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX) analysis, high calcium and phosphorus levels were detected at the interface with a thickness of about 10 microm. Intimate contact was also observed between the Sr-HA cement and cortical bone without fibrous layer intervening. The overall affinity index of bone on Sr-HA cement was (85.06 +/- 5.40)%, which is significantly higher than that on PMMA cement (2.77%+/- 0.49%). On the contrary, a fibrous layer was consistently observed between PMMA cement and bone, and PMMA cement evoked an inflammatory response and foreign body reaction in the surrounding bony tissues. Results suggested good bioactivity and bone-bonding ability of the Sr-HA cement under weight-bearing conditions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Strontium‐containing hydroxyapatite (Sr‐HA) bioactive cement for primary hip replacement: An in vivo study

Chiu

et al. 2005

J Biomed Mater Res

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“…Due to the relatively lower setting temperature (less than 65uC), the canals adjacent to the Sr-HA cement can survive. In contrast, PMMA cement has a high curing temperature, which damages cell activity, leading to necrosis [42]. Volkmann's canals, containing blood vessels, run perpendicular to the osteons.…”

Section: Sr-ha Cement-bone Interfacementioning

confidence: 99%

Development and clinical trial of a novel bioactive bone cement

Leong

2008

Front. Med. China

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Strontium (Sr) and related compounds have become more attractive in the prevention and treatment of osteoporosis. Previously, we developed a novel bioactive bone cement which is mainly composed of strontium-containing hydroxyapatite (Sr-HA) filler and bisphenol A diglycidylether dimethacrylate (Bis-GMA) resin. This bone cement is superior to conventional polymethylmethacrylate (PMMA) bone cement in bioactivity, biocompatibility, and osseointegration. It also has shown sufficient mechanical strength properties for its use in percutaneous vertebroplasty (PVP) and total hip replacement (THR). In this paper, we review the in vitro, in vivo and clinical evidence for the effectiveness of this bioactive bone cement.

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“…It does not degrade, and it can cause tissue incompatibility reactions. It has been shown to support bacterial growth, possibly by decreasing local inflammatory response, and to produce bone resorption and osteoblast toxicity [7][8][9][10]. Not all antibiotics can be incorpo-rated into PMMA, and up to 90% of the drug often remains bound within the matrix for extended periods of time [11].…”

Section: Introductionmentioning

confidence: 99%

In vivo Evaluation of Gentamicin Impregnated Polylactic Acid Beads Implanted in Sheep

Dernell¹,

Withrow²,

Kuntz³

et al. 2001

Journal of Bioactive and Compatible Polymers

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The biocompatibility and levels of gentamicin released from a poly(lactic acid) (PLA) polymer system in the serum, milk and tissue of a food animal model were determined. Microsphere particles of PLA containing 6.7% (w/w) gentamicin were compressed into 5 mm beads onto suture. Three groups of three cull ewes each were implanted with a bead string of PLA/gentamicin in one caudal thigh (muscle) and PLA control beads in the opposite thigh for 2, 4 and 6 months. Milk and serum samples were obtained at regular intervals until sacrifice. Following sacrifice, implant sites, kidney, liver and skeletal muscle were sampled for gentamicin concentration and histologic evaluation. Serum gentamicin peaked by day 1 (up to 0.7 μg/mL) and decreased to near zero by day 16 in all groups. Milk levels were measurable (>0.01 μg/mL) only on 2 days, in one sheep. Kidney gentamicin levels approached 2 ppm, and liver gentamicin levels approached 1 ppm in the 6-month group. A mild to moderate foreign body reaction was seen histologically in all PLA/gentamicin and PLA control implantation sites. Gentamicin released from this implanted polymer system produced low serum and milk concentrations, but developed renal accumulation beyond tolerated levels (30 ppb). Polymer/antibiotic delivery systems show promise for the treatment of local infections in veterinary patients.

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Characterization of tissue from the bone-polymethylmethacrylate interface in a rat experimental model. Demonstration of collagen-degrading activity and bone-resorbing potential.

Cited by 14 publications

References 0 publications

Strontium‐containing hydroxyapatite (Sr‐HA) bioactive cement for primary hip replacement: An in vivo study

Strontium‐containing hydroxyapatite (Sr‐HA) bioactive cement for primary hip replacement: An in vivo study

Development and clinical trial of a novel bioactive bone cement

In vivo Evaluation of Gentamicin Impregnated Polylactic Acid Beads Implanted in Sheep

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