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Cited by 42 publications
(64 citation statements)
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References 32 publications
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“…39 and 40), a process of unidirectional transfer of genetic material between members of a multigenic family (41). Gene conversion generates a transition from the heterozygous stage to the homozygous stage, and thus can result in substantial heterozygote deficiency (40). Given that we obtained similar findings across the 12 independent microsatellite loci, gene conversion could account for our findings only if it occurred among all of the loci studied, across the entire genome, which seems unlikely.…”
Section: Discussionmentioning
confidence: 52%
“…39 and 40), a process of unidirectional transfer of genetic material between members of a multigenic family (41). Gene conversion generates a transition from the heterozygous stage to the homozygous stage, and thus can result in substantial heterozygote deficiency (40). Given that we obtained similar findings across the 12 independent microsatellite loci, gene conversion could account for our findings only if it occurred among all of the loci studied, across the entire genome, which seems unlikely.…”
Section: Discussionmentioning
confidence: 52%
“…To test whether TcPolh is also involved in HR, TcPolg-overexpressing parasites were irradiated with high doses of gamma radiation, generating double-strand breaks in DNA. After gamma irradiation, T. cruzi cells arrest their growth and only begin to proliferate again after the DNA has been repaired [Regis-da-Silva et al, 2006]. As shown in Figure 8A, parasites overexpressing TcPolg exhibited a delay in growth return as compared to wild-type cells (Fig.…”
Section: Treatment Of T Cruzi Tcpolg-overexpressing Parasites With Omentioning
confidence: 89%
“…Wild-type Trypanosoma cruzi epimastigotes (CL Brener strain) cells, as well overexpressing TcRad51 cells [Regis-da-Silva et al, 2006] were used. Cells were grown at 288C in liver infusion tryptose (LIT) medium supplemented with 10% fetal calf serum (FCS), as described by Camargo [1964].…”
Section: Methodsmentioning
confidence: 99%
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“…The supernatant (conditioned medium) was saved for later use, and the cells were resuspended in PBS. DNA extraction and quantification, QPCR amplification, and analyses were conducted as reported previously (Regis-da- Silva et al 2006). The qPCR assay compared the amplification of the DNA from a treated sample with the amplification obtained with the untreated control.…”
Section: Analysis Of Dna Lesions Using Quantitative Pcr (Qpcr) Assaymentioning
confidence: 99%