Characterization of the T61 human breast carcinoma established in nude mice

Nonlinear Growth Kinetics of Breast Cancer Stem Cells: Implications for Cancer Stem Cell Targeted Therapy

“…It has been well-documented that the growth curve of breast cancer cells both in vitro and in vivo shows a Gompertzian shape but the underlying mechanism for the Gomperzian nature of tumor growth remains unknown252627. Here, we will explore the CSC hypothesis as an explanation for Gomertzian growth of tumors.…”

Nonlinear Growth Kinetics of Breast Cancer Stem Cells: Implications for Cancer Stem Cell Targeted Therapy

“…It has been well-documented that the growth curve of breast cancer cells both in vitro and in vivo shows a Gompertzian shape but the underlying mechanism for the Gomperzian nature of tumor growth remains unknown252627. Here, we will explore the CSC hypothesis as an explanation for Gomertzian growth of tumors.…”

The T61 human breast cancer xenograft: An experimental model of estrogen therapy of breast cancer

“…In brief, the T61 tumor was derived from the surgical specimen of a primary breast cancer of a 54-year-old postmenopausal woman who underwent mastectomy for an invasive ductal carcinoma of the breast (T1,N0,M0). A biopsy of the primary tumor was transplanted into castrated male nude mice Chromosome analysis performed in passage 21 revealed a human karyotype, confirming the human origin of T61 [14]. Analysis of estrogen and progesterone receptor content demonstrated saturable, high-affinity and ligand-specific binding of estrogen and progesterone to T61 tumor cytosol [14].…”

Endocrine therapy of human breast cancer grown in nude mice

“…It is evident from the data available on heterotransplanted human breast cancer that the tumors do retain biological characteristics of the donor tissue even after long-term serial transplantation [28,65]. Furthermore, tumors derived from cultured lines retain in vivo the biological characteristics of that line in vitro.…”

Nonlinear Growth Kinetics of Breast Cancer Stem Cells: Implications for Cancer Stem Cell Targeted Therapy

“…It has been well-documented that the growth curve of breast cancer cells both in vitro and in vivo shows a Gompertzian shape but the underlying mechanism for the Gomperzian nature of tumor growth remains unknown252627. Here, we will explore the CSC hypothesis as an explanation for Gomertzian growth of tumors.…”

The T61 human breast cancer xenograft: An experimental model of estrogen therapy of breast cancer

“…In brief, the T61 tumor was derived from the surgical specimen of a primary breast cancer of a 54-year-old postmenopausal woman who underwent mastectomy for an invasive ductal carcinoma of the breast (T1,N0,M0). A biopsy of the primary tumor was transplanted into castrated male nude mice Chromosome analysis performed in passage 21 revealed a human karyotype, confirming the human origin of T61 [14]. Analysis of estrogen and progesterone receptor content demonstrated saturable, high-affinity and ligand-specific binding of estrogen and progesterone to T61 tumor cytosol [14].…”

Endocrine therapy of human breast cancer grown in nude mice

“…It is evident from the data available on heterotransplanted human breast cancer that the tumors do retain biological characteristics of the donor tissue even after long-term serial transplantation [28,65]. Furthermore, tumors derived from cultured lines retain in vivo the biological characteristics of that line in vitro.…”

Nonlinear Growth Kinetics of Breast Cancer Stem Cells: Implications for Cancer Stem Cell Targeted Therapy

“…It has been well-documented that the growth curve of breast cancer cells both in vitro and in vivo shows a Gompertzian shape but the underlying mechanism for the Gomperzian nature of tumor growth remains unknown252627. Here, we will explore the CSC hypothesis as an explanation for Gomertzian growth of tumors.…”

The T61 human breast cancer xenograft: An experimental model of estrogen therapy of breast cancer

“…In brief, the T61 tumor was derived from the surgical specimen of a primary breast cancer of a 54-year-old postmenopausal woman who underwent mastectomy for an invasive ductal carcinoma of the breast (T1,N0,M0). A biopsy of the primary tumor was transplanted into castrated male nude mice Chromosome analysis performed in passage 21 revealed a human karyotype, confirming the human origin of T61 [14]. Analysis of estrogen and progesterone receptor content demonstrated saturable, high-affinity and ligand-specific binding of estrogen and progesterone to T61 tumor cytosol [14].…”

Endocrine therapy of human breast cancer grown in nude mice

“…It is evident from the data available on heterotransplanted human breast cancer that the tumors do retain biological characteristics of the donor tissue even after long-term serial transplantation [28,65]. Furthermore, tumors derived from cultured lines retain in vivo the biological characteristics of that line in vitro.…”