Characterization of the surface geometry of acetyl-[Leu 28,31 ]-NPY(24-36), a selective Y 2 receptor agonist, onto the Ag and Au surfaces

Domin, Helena; Święch, Dominika; Piergies, Natalia; Pięta, Ewa; Kim, Younkyoo; Proniewicz, Leonard M.

doi:10.1016/j.vibspec.2016.03.018

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…Whereas for the vertical orientation, it should be opposite . Based on the SERS selection rules together with the occurring changes in the relative intensities, the position and the width of bands in the SERS spectra in comparison with the Raman spectra, the interaction between molecule and the metal substrate, and even the distance of the individual functional groups with regards to this substrate can be determined …”

Section: Introductionmentioning

confidence: 99%

Identification of erlotinib adsorption pattern onto silver nanoparticles: SERS studies

Piergies

Oćwieja

Paluszkiewicz

et al. 2018

J Raman Spectroscopy

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In this study, we present surface‐enhanced Raman spectroscopy (SERS) investigations for the erlotinib adsorbed onto silver nanoparticles (AgNPs). The observed spectral patterns, namely, changes in width and wavenumber of the SERS bands in comparison with these occurring in the corresponding Raman spectrum suggest how the investigated drug interacts with the applied metal nanoparticles. Moreover, the physicochemical investigations including transmission electron microscope, UV–Vis spectroscopy, and electrophoretic mobility measurements were used for characterization of the nanoparticles and erlotinib/nanoparticles stability. Briefly, the performed measurements suggest that the erlotinib strong interacts with the applied AgNPs. Additionally, the studied interaction seems to be the strongest for the acetylene moiety, which undergoes deprotonation. Also the –CNH and –OCH3 groups play an important role in the erlotinib–metal nanoparticles interaction. This is opposite for the CH2, which is only in certain distance from this nanosurface. In the case of the aromatic rings the two different ways of interaction were recognized. The phenyl ring interacts rather weak with the AgNPs and is oriented perpendicular onto the surface. Whereas, the quanizoline moiety only participates in this interaction with more or less tilted orientation with regards to the AgNPs. On the other hand, the SERS analysis for the different erlotinib concentration indicates that the discussed interaction is sensitive for the drug dilution.

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Section: Introductionmentioning

confidence: 99%

Identification of erlotinib adsorption pattern onto silver nanoparticles: SERS studies

Piergies

Oćwieja

Paluszkiewicz

et al. 2018

J Raman Spectroscopy

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“…Moreover, polypeptides could affect the surface state of SERS substrate, which is in favor of the SERS enhancement. Helena Domin et al discussed the colloidal and electrochemically roughed Ag and Au substrates immobilized on polypeptides [ 91 ]. Some change in the surface geometry was observed, which is mainly due to the Tyrosine ring(s) being parallel to the substrates and in the close contact with the substrate surface.…”

Section: Bio-functionalization Engineering For Sers Biosensingmentioning

confidence: 99%

Recent development of surface-enhanced Raman scattering for biosensing

Lin

Peng

et al. 2023

J Nanobiotechnol

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Surface-Enhanced Raman Scattering (SERS) technology, as a powerful tool to identify molecular species by collecting molecular spectral signals at the single-molecule level, has achieved substantial progresses in the fields of environmental science, medical diagnosis, food safety, and biological analysis. As deepening research is delved into SERS sensing, more and more high-performance or multifunctional SERS substrate materials emerge, which are expected to push Raman sensing into more application fields. Especially in the field of biological analysis, intrinsic and extrinsic SERS sensing schemes have been widely used and explored due to their fast, sensitive and reliable advantages. Herein, recent developments of SERS substrates and their applications in biomolecular detection (SARS-CoV-2 virus, tumor etc.), biological imaging and pesticide detection are summarized. The SERS concepts (including its basic theory and sensing mechanism) and the important strategies (extending from nanomaterials with tunable shapes and nanostructures to surface bio-functionalization by modifying affinity groups or specific biomolecules) for improving SERS biosensing performance are comprehensively discussed. For data analysis and identification, the applications of machine learning methods and software acquisition sources in SERS biosensing and diagnosing are discussed in detail. In conclusion, the challenges and perspectives of SERS biosensing in the future are presented.

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“…The surface geometry of the neuropeptide Y (NPY) and its C-terminal fragments on AuNPs and AgNPs have also been studied. The results show that the NPY 32–36 C-terminal fragments were involved in the adsorption process on the metal substrate where tyrosine and arginine are mainly responsible for the interaction with the Ag and Au surfaces [ 47 , 48 ]. Peptides with tryptophan in different chain positions were also investigated with SERS and supported by DFT calculations.…”

Section: Neurological Diseasesmentioning

confidence: 99%

In Vitro and In Vivo SERS Biosensing for Disease Diagnosis

et al. 2018

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For many disease states, positive outcomes are directly linked to early diagnosis, where therapeutic intervention would be most effective. Recently, trends in disease diagnosis have focused on the development of label-free sensing techniques that are sensitive to low analyte concentrations found in the physiological environment. Surface-enhanced Raman spectroscopy (SERS) is a powerful vibrational spectroscopy that allows for label-free, highly sensitive, and selective detection of analytes through the amplification of localized electric fields on the surface of a plasmonic material when excited with monochromatic light. This results in enhancement of the Raman scattering signal, which allows for the detection of low concentration analytes, giving rise to the use of SERS as a diagnostic tool for disease. Here, we present a review of recent developments in the field of in vivo and in vitro SERS biosensing for a range of disease states including neurological disease, diabetes, cardiovascular disease, cancer, and viral disease.

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Characterization of the surface geometry of acetyl-[Leu 28,31 ]-NPY(24-36), a selective Y 2 receptor agonist, onto the Ag and Au surfaces

Cited by 5 publications

References 48 publications

Identification of erlotinib adsorption pattern onto silver nanoparticles: SERS studies

Identification of erlotinib adsorption pattern onto silver nanoparticles: SERS studies

Recent development of surface-enhanced Raman scattering for biosensing

In Vitro and In Vivo SERS Biosensing for Disease Diagnosis

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