Characterization of the fate of midline epithelial cells during the fusion of mandibular prominences in vivo

Chai, Yang; Sasano, Yasuyuki; Bringas, Pablo; Mayo, Mark L.; Kaartinen, Vesa; Heisterkamp, Nora; Groffen, John; Slavkin, Harold C.; Shuler, Charles F.

doi:10.1002/(sici)1097-0177(199704)208:4<526::aid-aja8>3.0.co;2-k

Cited by 25 publications

(13 citation statements)

References 17 publications

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“…Our microarray data also showed that the EMT-inducible transcription factor Snai1 and the Rho family (Rhoa, Rac1, and Cdc42) were either constitutive or L region-specific (data not shown). Taken with the report that knockout mice lacking Igfbp5 expression grow without defects in the orofacial architecture (Ning et al, 2006), we speculate that Igfbp5 localized in the mandibular epithelium may contribute to modulation in fine-tune of the epithelial integrity before the midline epithelium becomes ultimately incorporated within the oral epithelia covering the mandible (Chai, 1997). In connection with the epithelium-dominant Igfbp5 expression, the present IPA results indicated that Igfbp5 is a downstream target of Shh expressed exclusively in the M1-epi (Fig.…”

Section: Ipa Prediction Of Upstream Regulators Of Medial Region-specisupporting

confidence: 83%

“…On the other hand, in the primary palatogenesis, epithelial fusion between the lateral-nasal and maxillary prominences begins in a small area and pressure from growth in the apposed mesenchyme subsequently pushes out the intervening epithelium (Minkof, 1980;Bailey et al, 1988;Diewert and Wang, 1992). This is also the case for the fusion of the mandibular prominences and the epithelial cells become incorporated within the oral epithelia that ultimately cover the mandible (Chai et al, 1997). This sequence of fusion events was originally described as a 'merging' (Patten, 1961).…”

Section: Introductionmentioning

confidence: 97%

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Molecular signaling at the fusion stage of the mouse mandibular arch: involvement of insulin-like growth factor family

Fujita¹,

Taya²,

Shimazu³

et al. 2013

Int. J. Dev. Biol.

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Fusion of the branchial arch derivatives is a crucial event in the development of the craniofacial architecture. Here, we surveyed the gene expression profile, focusing on the fusion process of the mouse mandibular arch at embryonic day 10.5. In order to identify the genes that are relevant to the midline fusion process, we subdivided the mandibular arch medially and laterally, and determined gene expression using microarray and real-time quantitative PCR. By comparing the transcriptomes of the medial and lateral regions, 362 genes were identified as medial regionspecific genes, while 346 genes were designated lateral region-specific. Taken with Gene Ontology analysis, KEGG pathways and Ingenuity Pathway Analysis (IPA), a survey of the medial regionspecific gene dataset revealed significant expression of the insulin-like growth factor (Igf) family as well as other growth factor families (Hh, Wnt, Tgf-Bmp, Mapk-Fgf and Notch). To determine the discrete expression pattern of Igf family genes in the medial region, we microdissected the medial part of the mandibular arch into epithelial and mesenchymal components, and found that Igf1 was highly expressed in the mesenchyme, Igf2 and Igf1r were expressed in both the midline epithelium and surrounding mesenchyme, and Igfbp5 was highly expressed in the epithelium. Immunohistochemical findings validated the regional Igf gene expression profiles. Our observations suggest that in the "merging" fusion of the mandibular arch, the Igf cascade may contribute to generation of proliferation pressure from the mesenchyme and preservation of epithelial phenotypes and architecture during mesenchymal confluence.

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Section: Ipa Prediction Of Upstream Regulators Of Medial Region-specisupporting

confidence: 83%

Section: Introductionmentioning

confidence: 97%

Molecular signaling at the fusion stage of the mouse mandibular arch: involvement of insulin-like growth factor family

Fujita¹,

Taya²,

Shimazu³

et al. 2013

Int. J. Dev. Biol.

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“…Mandibular development depends upon the interaction between the oral ectoderm and the CNC-derived mesenchyme within the first branchial arch. Within the oral ectoderm, signaling molecules, such as BMP, TGF-␤, and FGF, are expressed in a region-specific manner (Chai et al, 1994(Chai et al, , 1997Trumpp et al, 1999;Ito et al, 2002;Liu et al, 2005). They may regulate homeobox-containing genes (such as Dlx, Lhx, and Gsc) within the CNC-derived mesenchyme to generate early polarity and are responsible for patterning of the first branchial arch.…”

Section: Mandibular Morphogenesismentioning

confidence: 99%

Recent advances in craniofacial morphogenesis

Chai

Maxson

2006

Developmental Dynamics

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535

503

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Craniofacial malformations are involved in three fourths of all congenital birth defects in humans, affecting the development of head, face, or neck. Tremendous progress in the study of craniofacial development has been made that places this field at the forefront of biomedical research. A concerted effort among evolutionary and developmental biologists, human geneticists, and tissue engineers has revealed important information on the molecular mechanisms that are crucial for the patterning and formation of craniofacial structures. Here, we highlight recent advances in our understanding of evo-devo as it relates to craniofacial morphogenesis, fate determination of cranial neural crest cells, and specific signaling pathways in regulating tissue-tissue interactions during patterning of craniofacial apparatus and the morphogenesis of tooth, mandible, and palate. Together, these findings will be beneficial for the understanding, treatment, and prevention of human congenital malformations and establish the foundation for craniofacial tissue regeneration. Developmental Dynamics 235:2353-2375, 2006.

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“…The mechanisms for removal of the epithelial cells that results in mesenchymal continuity in facial processes are thought to be mediated by either programmed cell death (apoptosis), epithelial-mesenchymal transformation, or migration to adjacent epithelia (Shuler, 1995 epithelial cell migration (Shuler et al, 1992;Shuler, 1995;Chai et al, 1997;McGonnell et al, 1998). Studies in the mouse embryo indicate that merger of the 2 mandibular processes starts at E9.5 and is completed within 24 to 36 hrs at Ell (Chai et al, 1997). During this process, the epithelium covering the tips of the mandibular processes consists of 2 cell layers that adhere to each other and subsequently fuse to form an epithelial seam about 3 or 4 cell layers thick.…”

Section: Epidermal Growth Factor (Egf)mentioning

confidence: 99%

Regulation of Mandibular Growth and Morphogenesis

Mina

2001

Critical Reviews in Oral Biology & Medicine

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The development of the vertebrate face is a dynamic process that starts with the formation of facial processes/prominences. Facial processes are small buds made up of mesenchymal masses enclosed by an epithelial layer that surround the primitive mouth. The 2 maxillary processes, the 2 lateral nasal processes, and the frontonasal processes form the upper jaw. The lower jaw is formed by the 2 mandibular processes. Although the question of the embryonic origin of facial structures has received considerable attention, the mechanisms that control differential growth of the facial processes and patterning of skeletal tissues within these structures have been difficult to study and still are not well-understood. This has been partially due to the lack of readily identifiable morphologically discrete regions in the developing face that regulate patterning of the face. Nonetheless, in recent years there has been significant progress in the understanding of the signaling network controlling the patterning and development of the face (for review, see Richman et al., 1991;Francis-West et al., 1998). This review focuses on current understanding of the processes and signaling molecules that are involved in the formation of the mandibular arch.

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Characterization of the fate of midline epithelial cells during the fusion of mandibular prominences in vivo

Cited by 25 publications

References 17 publications

Molecular signaling at the fusion stage of the mouse mandibular arch: involvement of insulin-like growth factor family

Molecular signaling at the fusion stage of the mouse mandibular arch: involvement of insulin-like growth factor family

Recent advances in craniofacial morphogenesis

Regulation of Mandibular Growth and Morphogenesis

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