2011
DOI: 10.1002/jcp.22629
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Abstract: Most acute coronary events occur in the upstream region of stenotic atherosclerotic plaques that experience laminar shear stress (LSS) elevated above normal physiological levels. Many studies have described the atheroprotective effect on endothelial behavior of normal physiological LSS (approximately 15 dynes/cm2) compared to static or oscillatory shear stress (OSS), but it is unknown whether the levels of elevated shear stress imposed by a stenotic plaque would preserve, enhance or reverse this effect. Theref… Show more

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Cited by 106 publications
(69 citation statements)
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“…In a recent comprehensive descriptive study, Pandey et al (157) reported that Nox5 is present in human saphenous vein and internal mammary artery, cultured human VSMCs, and endothelium, but not in fibroblasts, with the a and b isoforms being most abundant in vascular cells. Adenovirus-mediated overexpression of Nox5 promoted phosphorylation of MAPK in ECs and VSMCs (195), which is similar to our studies in Ang II-stimulated Nox5-containing cells (151,228). These studies, although informative of human Nox expression, have limitations, as they are essentially descriptive and do not reveal much insight into the mechanisms of oxidative stress.…”
Section: Ros and Noxs In Human Vesselssupporting
confidence: 83%
“…In a recent comprehensive descriptive study, Pandey et al (157) reported that Nox5 is present in human saphenous vein and internal mammary artery, cultured human VSMCs, and endothelium, but not in fibroblasts, with the a and b isoforms being most abundant in vascular cells. Adenovirus-mediated overexpression of Nox5 promoted phosphorylation of MAPK in ECs and VSMCs (195), which is similar to our studies in Ang II-stimulated Nox5-containing cells (151,228). These studies, although informative of human Nox expression, have limitations, as they are essentially descriptive and do not reveal much insight into the mechanisms of oxidative stress.…”
Section: Ros and Noxs In Human Vesselssupporting
confidence: 83%
“…Instead, entirely different responses might be induced in different WSS regimes. Both we (8) and White et al (53) reported that high WSS induces expression patterns that are quite distinct from baseline WSS, which in turn affects ECs very differently from below-normal WSS. Thus different magnitudes of WSS turn different responses on or off, and important thresholds may exist in vivo that distinguishes among trophic and protective flow, repair and remodeling environments, and pathology-inducing conditions.…”
Section: Effects Of High Wss Alonementioning
confidence: 58%
“…22 Evidence from human and animal studies suggests that chronic hypertension is associated with inflammation. [23][24][25] As to whether hypertension activates the inflammatory cascade or vice versa is not well understood. However, Aoki et al elegantly showed that hemodynamic stress activates PGE 2 -EP 2 signaling in the endothelial cells and leads to CA formation.…”
Section: Chronic Hypertension and Cerebral Aneurysmsmentioning
confidence: 99%