Characterization of submicron emulsion processed by ultrasound homogenization to protect a bioactive extract from sea grape (Coccoloba uvifera L.)

Microencapsulation of Phenolic Extract from Sea Grape (Coccoloba uvifera L.) with Antimutagenic Activity

“…The solubility of microparticles was 76.0±3.60 %, this value is related to the hydrophilic properties of MD [26] . The water‐insoluble percentage (∼24 %) was attributable to the miglyol (oil used as an emulsifier in the formulation developed in this research) and extract’ insoluble fraction, including phenols and proteins, that can develop stable complexes with polysaccharides [3,27] . This result agrees with a previous solubility value (70 %) reported for jackfruit extract microencapsulated with MD [8] .…”

“…Instead, the first decomposition step to SE ranged from 25 to 65 °C (2.90±0.32 %). The weight loss in this step was associated with loss of moisture and extract volatile fraction [3,8] . In the second step, 19.94 % of the extract (129–200 °C) decomposed, corresponding to extract solids decomposition, mainly composed of phenols and anthocyanins [3] .…”

“…In line with this, the consumption of high biological value compounds (HBVC) from plants such as polyphenols, carotenoids, flavonoids, and others has been increased due to their biological activity, particularly related to their antioxidant and antimutagenic activities [2] . Sea grape ( Coccoloba uvifera L.) is considered a great source of nutrients and HBVC such as anthocyanins (cyanidin 3‐glucoside, malvidin 3‐glucoside, and delphinidin 3‐glucoside), [3] comparable to fruits such as orange, apple, and kiwi [4] . Once HBVC are extracted from the fruit matrix are highly susceptible to structural changes associated with environmental conditions such as high temperature, humidity, oxygen, and ultraviolet (UV) light, losing their biological properties [5] .…”

Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides

“…Submicroemulsion is a colloidal dispersion system with liquid fat oil as the core, phospholipids as the main emulsifier, and the droplet size of submicroemulsion is between emulsion and microemulsion. It has the characteristics of good stability, good antitumor effect and low toxicity [ 135 ]. In addition, by incorporating the drugs into the oil phase and interfacial layer, this delivery system could reduce irritation and toxicity, increase solubility and stability, as well as offer the possibility of sustained release.…”

Use of jackfruit leaf (Artocarpus heterophyllus L.) protein hydrolysates as a stabilizer of the nanoemulsions loaded with extract-rich in pentacyclic triterpenes obtained from Coccoloba uvifera L. leaf

“…Coccoloba uvifera L. (sea grape) is a fruit rich in phytochemicals like polyphenols, flavonoids, and anthocyanins, which give it antioxidant properties ( Ramos-Bell, Calderón-Santoyo, Barros-Castillo, & Ragazzo-Sánchez, 2020 ), while Coccoloba uvifera L. leaf extract is a source with high content of pentacyclic triterpenes (PTs) such as lupeol, α- and β-amyrin ( Ramos-Hernández, Calderón-Santoyo, Navarro-Ocaña, Barros-Castillo, & Ragazzo-Sánchez, 2018 ). PTs are high-value biological compounds (HVBC) that, in recent years, have aroused interest due to their comprehensive spectrum of biological activities ( Salvador et al, 2017 ).…”