J. Neurosci. Res. volume 87, issue 5, P1219-1229 2009 DOI: 10.1002/jnr.21933 View full text
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Janos Luckl, Chao Zhou, Turgut Durduran, Arjun G. Yodh, Joel H. Greenberg

Abstract: Little information exists on the role and the characteristics of perfusion changes related to periinfarct depolarization. Our aim was to visualize and monitor periinfarct flow transients (PIFTs) in Sprague-Dawley rats (n 5 10) with two different laser methods in a closed-skull model of filament middle cerebral artery occlusion. A laser Doppler probe was placed over the ischemic cortex 5 mm lateral to Bregma, and a 5 3 5 mm area centered 5 mm posterior and 4 mm lateral to Bregma was thinned for laser speckle i…

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