Characterization of olive pomace extract obtained by cyclodextrin-enhanced pulsed ultrasound assisted extraction

Influence of Pomace Matrix and Cyclodextrin Encapsulation on Olive Pomace Polyphenols’ Bioaccessibility and Intestinal Permeability

“…Namely, lipid peroxidation (as a chain reaction that lead to deleterious cell membrane damage) can be initiated by dietary fats.Considering its phenolic composition, olive pomace is very similar to olive oil and represents an inexpensive and readily available source of HTS derivatives. In the last decade, the potential of the olive pomace as a rich source of biologically active compounds has been recognized in scientific and professional literature, resulting in the development of a large number of effective extraction procedures [6,7]. However, the poor technological properties of raw olive pomace extracts (OPE) limit their wider application as nutraceuticals and food additives [7].…”

“…In the last decade, the potential of the olive pomace as a rich source of biologically active compounds has been recognized in scientific and professional literature, resulting in the development of a large number of effective extraction procedures [6,7]. However, the poor technological properties of raw olive pomace extracts (OPE) limit their wider application as nutraceuticals and food additives [7]. The main prerequisites for obtaining usable OPE are high yield of HTS derivatives, stability, and satisfactory technological properties of dry extracts.…”

“…The main prerequisites for obtaining usable OPE are high yield of HTS derivatives, stability, and satisfactory technological properties of dry extracts. In this regard, cyclodextrins (CDs) were successfully applied for achieving higher polyphenol yields and the formulation of stable and organoleptically acceptable olive pomace extracts (OPEs) [7]. Moreover, α-CD, β-CD, and γ-CD are listed on the generally regarded as safe (GRAS) list of the U.S. Food and Drug Administration (FDA) for use as a food additive [8][9][10].In addition to demonstrating favorable chemical composition and technological properties, the quality of OPE is significantly determined by bioavailability and biological activity of its main active components.…”

“…Recently, Malapert and co-workers [15] investigated the bioaccessibility of HTS from Alperujo in Caco-2 cells, showing generally low availability of HTS, additionally reduced by the Alperujo matrix or concomitant food intake.Such strong matrix effects on bioaccessibility of biologically active nutraceuticals can be reduced by significant extent by innovative formulation approaches; therefore, the use of pharmaceutical excipients and advanced formulations for oral administration of nutraceuticals has recently been intensified [16].Among relatively simple but effective approaches is the formulation of nutraceutical-cyclodextrin inclusive complexes. This approach has recently been successfully applied in formulation of OPE-derived extracts and resulted in improved physical-chemical properties of dry extracts, increased shelf life, and higher antioxidant activity in different food-and biological model systems [7,17].However, the presence of particular CD in OPE can have significant impact on the bioaccessibility and intestinal permeability of OPE polyphenols. CDs are cyclic oligosaccharides used for the improvement of water-solubility and bioavailability of medicinal products.…”

“…Among relatively simple but effective approaches is the formulation of nutraceutical-cyclodextrin inclusive complexes. This approach has recently been successfully applied in formulation of OPE-derived extracts and resulted in improved physical-chemical properties of dry extracts, increased shelf life, and higher antioxidant activity in different food-and biological model systems [7,17].…”