Characterization of Micro RNA Signature in Peripheral Blood of Schizophrenia Patients using µParafloTM miRNA Microarray Assay

Vachev, Tihomir; Popov, Nikolay T.; Marchev, Danail; Ivanov, Hristo; Stoyanova, Vili K.

doi:10.20546/ijcmas.2016.507.055

Cited by 4 publications

(2 citation statements)

References 9 publications

(13 reference statements)

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“…Besides, CTDSPL co-expressed with many SCZ risk genes, such as NOTCH2 , DOCK7 , and SPON1 , which mainly changed in astrocytes, as shown by PsychENCODE ( Gandal et al., 2018 ; Wang et al., 2018 ) and our database-based analysis. Furthermore, mir-183-5p, a microRNA that can regulate CTDSPL , has also been found to be down-regulated in the blood cell of patients with SCZ ( Vachev et al., 2016 ). All the evidence is consistent with our findings, suggesting that the under-transmission of CTDSPL at 3p22.2 from healthy parents to the probands may lead to a decline in CTDSPL expression and then play a role in the etiology of SCZ.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide study of copy number variation implicates multiple novel loci for schizophrenia risk in Han Chinese family trios

Cong

Shen

et al. 2021

iScience

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Summary Schizophrenia (SCZ) is a severe neuropsychiatric disorder that affects 1% of the global population. Copy number variations (CNVs) have been shown to play a critical role in its pathophysiology; however, only case-control studies on SCZ susceptibility CNVs have been conducted in Han Chinese. Here, we performed an array comparative genomic hybridization-based genome-wide CNV analysis in 100 Chinese family trios with SCZ. Burden test suggested that the SCZ probands carried more duplications than their healthy parents and unrelated healthy controls. Besides, five CNV loci were firstly reported to be associated with SCZ here, including both unbalanced transmitted CNVs and enriched de novo CNVs. Moreover, two genes ( CTDSPL and MGAM ) in these CNVs showed significant SCZ relevance in the expression level. Our findings support the crucial role of CNVs in the etiology of SCZ and provide new insights into the underlying mechanism of SCZ pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Genome-wide study of copy number variation implicates multiple novel loci for schizophrenia risk in Han Chinese family trios

Cong

Shen

et al. 2021

iScience

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“…Face memory produced a significant peak on chromosome 3p21 in KIF15 , which colocalizes in dendrites and growth cones of axons with microtubules and is differentially expressed in fetal vs mature astrocytes . KIF15 is also a target of microRNA miR-192-5p, which has been shown to be downregulated in schizophrenia …”

Section: Discussionmentioning

confidence: 99%

Genome-wide Association of Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia (COGS) Study

et al. 2019

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IMPORTANCE The Consortium on the Genetics of Schizophrenia (COGS) uses quantitative neurophysiological and neurocognitive endophenotypes with demonstrated deficits in schizophrenia as a platform from which to explore the underlying neural circuitry and genetic architecture. Many of these endophenotypes are associated with poor functional outcome in schizophrenia. Some are also endorsed as potential treatment targets by the US Food and Drug Administration. OBJECTIVE To build on prior assessments of heritability, association, and linkage in the COGS phase 1 (COGS-1) families by reporting a genome-wide association study (GWAS) of 11 schizophrenia-related endophenotypes in the independent phase 2 (COGS-2) cohort of patients with schizophrenia and healthy comparison participants (HCPs). DESIGN, SETTING, AND PARTICIPANTS A total of 1789 patients with schizophrenia and HCPs of self-reported European or Latino ancestry were recruited through a collaborative effort across the COGS sites and genotyped using the PsychChip. Standard quality control filters were applied, and more than 6.2 million variants with a genotyping call rate of greater than 0.99 were available after imputation. Association was performed for data sets stratified by diagnosis and ancestry using linear regression and adjusting for age, sex, and 5 principal components, with results combined through weighted meta-analysis.

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Genetic Influences on Cognitive Dysfunction in Schizophrenia

Greenwood

2022

Current Topics in Behavioral Neurosciences

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Characterization of Micro RNA Signature in Peripheral Blood of Schizophrenia Patients using µParafloTM miRNA Microarray Assay

Cited by 4 publications

References 9 publications

Genome-wide study of copy number variation implicates multiple novel loci for schizophrenia risk in Han Chinese family trios

Genome-wide study of copy number variation implicates multiple novel loci for schizophrenia risk in Han Chinese family trios

Genome-wide Association of Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia (COGS) Study

Genetic Influences on Cognitive Dysfunction in Schizophrenia

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