volume 93, issue 0, P2-P-214 2020
DOI: 10.1254/jpssuppl.93.0_2-p-214
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Abstract: Sjogren's syndrome (SS) is a disease that presents dry eye and mouth with chronic inflammation of exocrine glands, such as lacrimal gland (LG). The causal treatment of SS has not been established since the mechanism of exocrine secretion remains unclear. Non-obese diabetes (NOD) mice, which present a leukocytic infiltrate of exocrine glands, are used as SS model. Here, we investigated lacrimal hyposecretion in male NOD mice and characterized the LG. Male mice were used at ages 4, 6, and 10 weeks. In NOD mice, …

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