Zhiheng Liu, Haihao Zhu, Guang Guang Fang, Kathryn Walsh, Mkaya Mwamburi, Benjamin Wolozin, Samer O. Abdul-Hay, Tsuneya Ikezu, Malcolm A. Leissring, Wei Qiao Qiu
Sporadic Alzheimer’s disease (AD) patients have low amyloid-β peptide (Aβ) clearance in the central nervous system (CNS). The peripheral Aβ clearance may also be important but its role in AD remains unclear. We aimed to study the Aβ degrading proteases including insulin degrading enzyme (IDE), angiotensin converting enzyme (ACE) and others in blood. Using the fluorogenic substrate V—a substrate of IDE and other metalloproteases, we showed that human serum degraded the substrate V, and the activity was inhibit…
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