Characterization ofPseudomonas aeruginosaIsolates: Occurrence Rates, Antimicrobial Susceptibility Patterns, and Molecular Typing in the Global SENTRY Antimicrobial Surveillance Program, 1997–1999

Abstract

During 1997-1999, a total of 70,067 isolates (6631 Pseudomonas aeruginosa isolates) were analyzed in the SENTRY program by geographic region and body site of infection. The respiratory tract was the most common source of P. aeruginosa. P. aeruginosa isolation rates increased during the study interval. Europe was the only region to show a significant decline in beta-lactam and aminoglycoside susceptibility rates. There was a reduction in the rates of susceptibility of Canadian isolates to imipenem and of Latin American isolates to meropenem. A total of 218 multidrug-resistant P. aeruginosa isolates (MDR-PSA; resistant to piperacillin, ceftazidime, imipenem, and gentamicin) were observed; MDR-PSA occurrence rates (percentages of all isolates) ranged from 8.2% (Latin America) to 0.9% (Canada). No antimicrobial inhibited >50% of MDR-PSA strains. Molecular characterization of selected, generally resistant strains was performed. Isolates showing unique ribogroups were found in Europe, Latin America, and the United States, but clonal spread was documented in several medical centers.

Clinical and microbiological characteristics of thoracic empyema: retrospective analysis in a tertiary care centre

“…13 All isolates of E.coli, Acinetobacter and Proteus were resistant to Ceftazidime. High mean levels of resistance to widely used anti-pseudomonal, Ceftazidime is a cause for concern.…”

Fatal diarrhea caused by multidrug resistant Pseudomonas aeruginosa in a foal from Rio de Janeiro, Brazil

“…Pseudomonas aeruginosa is a Gram negative microrganism that can be found in animal hosts and environment (Janam et al, 2011). This bacteria are known to be a major agent of infections in human hospitals, and has also been reported as opportunistic agent in animals (Kidd et al, 2011).…”

“…This bacteria are known to be a major agent of infections in human hospitals, and has also been reported as opportunistic agent in animals (Kidd et al, 2011). In horses, it has been associated to endometritis leading to reduced fertility (Kidd et al, 2011).…”

“…Thus, antimicrobial susceptibility testing should be a crucial step to select appropriate therapy. Multidrug resistant P. aeruginosa (MDRPA) were defined as strains resistant to piperacillin, ceftazidime, imipenem and gentamicin (Gales et al, 2001;Paramythiotou et al, 2004).…”

Quantifying the Impact of Bacterial Fitness and Repeated Antimicrobial Exposure on the Emergence of Multidrug-Resistant Gram-Negative Bacilli

“…Although methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) have been the major focus of investigations and preventive efforts, it has become clear over the last few years that the rate of hospital-acquired infections caused by multidrug-resistant gramnegative bacteria are quickly surpassing those caused by VRE and MRSA [9,13,15,16,24]. In one healthcare institution, MDR-P aeruginosa recovered form clinical cultures increased from 1 % in 1994 to 16 % in 2002, with similar dramatic increases among other species of gram-negative bacteria [9].…”