2014
DOI: 10.1111/mmi.12480
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Abstract: Cell walls are essential for fungal survival and growth. Fungal walls are ∼ 90% carbohydrate, mostly types not found in humans, making them promising targets for anti-fungal drug development. Echinocandins, which inhibit the essential β-glucan synthase, are already clinically available. In contrast, α-glucan, another abundant fungal cell wall component has attracted relatively little research attention because it is not essential for most fungi. Aspergillus nidulans has two α-glucan synthases (AgsA and AgsB) a… Show more

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Cited by 39 publications
(107 citation statements)
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“…In static liquid medium, A. nidulans undergoes its complete asexual life cycle. Conidiophores with conidia were seen when we collected the static samples at 24 h. Unlike amyD that had a general high basal expression [10], we found amyC and amyE maintained low expression levels throughout the A. nidulans asexual life cycle (Table 1). This conclusion was based on high Ct values of amyC and amyE in qPCR (data not shown).…”
Section: Resultsmentioning
confidence: 81%
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“…In static liquid medium, A. nidulans undergoes its complete asexual life cycle. Conidiophores with conidia were seen when we collected the static samples at 24 h. Unlike amyD that had a general high basal expression [10], we found amyC and amyE maintained low expression levels throughout the A. nidulans asexual life cycle (Table 1). This conclusion was based on high Ct values of amyC and amyE in qPCR (data not shown).…”
Section: Resultsmentioning
confidence: 81%
“…In our previous work, we reported that AmyD repressed α-glucan synthesis, and so we hypothesized that AmyD might work together with one or more α-1,3-glucanases to degrade α-glucan [10]. In order to understand the mechanism of AmyD as an α glucanase, it is important to determine its localization.…”
Section: Resultsmentioning
confidence: 99%
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