Biochemical Pharmacology volume 79, issue 6, P908-920 2010 DOI: 10.1016/j.bcp.2009.10.020 View full text
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Irina Vetter, Richard J. Lewis

Abstract: An increasing number of putative therapeutic targets have been identified in recent years for the treatment of neuronal pathophysiologies including pain, epilepsy, stroke and schizophrenia. Many of these targets signal through calcium (Ca(2+)), either by directly facilitating Ca(2+) influx through an ion channel, or through activation of G proteins that couple to intracellular Ca(2+) stores or voltage-gated Ca(2+) channels. Immortalized neuronal cell lines are widely used models to study neuropharmacology. How…

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