1999
DOI: 10.1088/0967-3334/20/3/301
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Abstract: Knowledge of human blood-flow waveforms is required for in vitro investigations and numerical modelling. Parameters of interest include: velocity and flow waveform shapes, inter- and intra-subject variability and frequency content. We characterized the blood-velocity waveforms in the left and right common carotid arteries (CCAs) of 17 normal volunteers (24 to 34 years), analysing 3560 cardiac cycles in total. Instantaneous peak-velocity (Vpeak) measurements were obtained using pulsed-Doppler ultrasound with si… Show more

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Cited by 286 publications
(206 citation statements)
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“…In clinical studies, it is generally assumed that the velocity profile is either flat or parabolic and that the BVF is proportional to the maximum velocity waveform [10,17,26,28,30]. It is widely believed that the Womersley profile approach [41], incorporating the pulsatile behavior of the BVF, delivers more physiological waveforms than the quasi-static (parabolic) Poiseuille profile approximation.…”
Section: Introductionmentioning
confidence: 99%
“…In clinical studies, it is generally assumed that the velocity profile is either flat or parabolic and that the BVF is proportional to the maximum velocity waveform [10,17,26,28,30]. It is widely believed that the Womersley profile approach [41], incorporating the pulsatile behavior of the BVF, delivers more physiological waveforms than the quasi-static (parabolic) Poiseuille profile approximation.…”
Section: Introductionmentioning
confidence: 99%
“…[2] and [6], computer simulations were performed to determine the inversion efficiency of the PCASL method. Using the PCASL labeling parameters specified above, the Bloch equations were simulated for a laminar flow profile with mean flow 19.5 cm/s, the cycle-averaged flow velocity found in the common carotid arteries (23). Computations were performed in the Java programming language (JDK 1.6.0, Sun Microsystems, Santa Clara, CA) and consisted of simulating the magnetization evolution for flowing arterial isochromats (T 1 ¼ 1.2 s and T 2 ¼ 0.2 s) experiencing the RF pulses and magnetic field gradients applied during the pseudocontinuous labeling phase, as well as T 1 and T 2 relaxation using a 1.0 ms time step.…”
Section: Theoretical Signal Predictionsmentioning
confidence: 99%
“…A flow profile of the average carotid artery blood velocity was obtained using Doppler ultrasound and was normalized to a peak velocity (v peak ) and duration of cardiac cycle (RR interval) of 1082 mm s -1 and 0.917 s, respectively (11). Velocities and RR intervals at the extremes of normal intersubject ranges were also investigated.…”
Section: Velocitymentioning
confidence: 99%