Characterization of Chitosan-Hybridized Diatomite as Potential Delivery Systems of Oxaliplatin and 5-Fluorouracil Drugs: Equilibrium and Release Kinetics
Haifa E. Alfassam,
Sarah I. Othman,
May N. Bin Jumah
et al.
Abstract:The current work involves the modification of diatomite’s
biosiliceous frustules employing chitosan polymer chains (CS/Di) to
serve as low-cost, biocompatible, multifunctional, and enhanced pharmaceutical
delivery systems for 5-fluorouracil (5-Fu) together with oxaliplatin
(OXPL). The CS/Di carrier displayed strong loading characteristics,
notably at saturation (249.17 mg/g (OXPL) and 267.6 mg/g (5-Fu)),
demonstrating a substantial 5-Fu affinity. The loading of the two
types of medications onto CS/Di was condu… Show more
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