Characterization of brain development with neuroimaging in a female mouse model of chemotherapy treatment of acute lymphoblastic leukemia
Kellen Gandy,
Timothy R. Koscik,
Tyler Alexander
et al.
Abstract:Background
Survivors of pediatric acute lymphoblastic leukemia (ALL) exhibit abnormal neurocognitive outcomes that are possibly due to exposures to neurotoxic chemotherapy agents. This study aimed to determine the feasibility of characterizing long-term neuroanatomical changes with
in vivo
neuroimaging in a preclinical model of treatment for ALL.
Methods
Female mice (C57BL/6) were randomly assigned to a saline control group (n=10) or a treatme… Show more
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