Characterization of Bone Substitute &amp;#946;-TCP Block for Maxillofacial Reconstruction

Alister, Juan Pablo; Uribe, Francisca; Vásquez, Bélgica; Fariña, R; Olate, Sérgio

doi:10.4067/s0717-95022019000100082

Cited by 5 publications

(5 citation statements)

References 40 publications

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“…In groups 1 and 2 the repair was endochondral (indirect) and in group 3 (distance between the bone ends of 8 mm) there was no fracture consolidation; the gap was comprised mainly of fibrous tissue with abundant fibroblasts, without osteoplastic integration. On the same hand, in groups 1 and 2 bone formation in the lateral area of the defect was observed clinically, maybe related to the contact of this area with the periosteal tissue, as related by Alister et al [20]; in the 8 mm bone gap this bone repair was not observed.…”

Section: Discussionmentioning

confidence: 64%

Histological Analysis of Bone Repair in Mandibular Body Osteotomy Using Internal Fixation System in Three Different Gaps without Bone Graft in an Animal Model

Olate

Vásquez

Sandoval

et al. 2019

BioMed Research International

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The aim was to analyze histologically the bone repair in a mandibular osteotomy model with different gaps between the segments. Nine male rabbits who underwent osteotomies on the mandibular body were fixed with a 1.5 system plate and no bone graft; group 1 (2 mm gap between segments), group 2 (5 mm gap between segments), and group 3 (8 mm gap between segments) were included. After 8 weeks they were euthanized and the sample was processed for histological analysis. Group 1 showed advanced bone repair with cartilaginous tissue and cancellous bone, showing osteoblasts and type III collagenous fibers. In group 2, a more delayed ossification was observed, with an extensive area of peripheral ossifying cartilage and chondrocytes in greater number at the center of the defect; group 3 showed no evidence of ossification with fibrous tissue, a very low level of chondrocytes, and some bone sequestrate. We can conclude that, in this animal model, 2 or 5 mm gap in the osteotomy could be repaired as bone when fixation is used. The size of the gap is an important factor for the use of bone grafts considering endochondral ossification. This model can be used for graft analysis and related technologies.

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Section: Discussionmentioning

confidence: 64%

Histological Analysis of Bone Repair in Mandibular Body Osteotomy Using Internal Fixation System in Three Different Gaps without Bone Graft in an Animal Model

Olate

Vásquez

Sandoval

et al. 2019

BioMed Research International

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“…Furthermore, in the struts of both HC-Ss ( Figure 1 e) and HC-Rs ( Figure 1 f), micropores were present between the spherical aggregates consisting of scale-like crystals. Many researchers previously demonstrated that micropores improved osteogenesis [ 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. Therefore, the micropores in the HC-Ss and HC-Rs may also contribute to bone regeneration.…”

Section: Resultsmentioning

confidence: 99%

Channel Aperture Characteristics of Carbonate Apatite Honeycomb Scaffolds Affect Ingrowths of Bone and Fibrous Tissues in Vertical Bone Augmentation

et al. 2022

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Synthetic scaffolds with the ability to prevent fibrous tissue penetration and promote bone augmentation may realize guided bone regeneration without the use of a barrier membrane for dental implantation. Here, we fabricated two types of honeycomb scaffolds of carbonate apatite, a bone mineral analog, whose channel apertures were square (HC-S) and rectangular (HC-R). The side lengths of the HC-Ss and HC-Rs were 265.8 ± 8.9; 817.7 ± 2.4 and 267.1 ± 5.2 μm, respectively. We placed cylindrical HC-Ss and HC-Rs on the rabbit calvaria. At 4 weeks post-implantation, the HC-Ss prevented fibrous tissue penetration from the top face via the channels, which allowed the new bone to reach the top of the scaffold from the bottom face or the calvarium. In contrast, in the HC-Rs, fibrous tissues filled the channels in the top region. At 12 weeks post-implantation, the HC-Ss were partially replaced with new bone. In the top region of the HC-Rs, although new bone had formed, fibrous tissue remained. According to the findings here and in our previous study, the longer side length rather than the shorter side length of a rectangular scaffold channel aperture is the dominant factor that affects fibrous tissue penetration and new bone augmentation. Furthermore, even though channel aperture areas are similar, bone and fibrous tissue ingrowths are different when the aperture shapes are different.

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“…Macro/microporosity is one of the main factors that affect the resorption of β -TCP because it allows the growth of blood vessels and osteocytic dendrites through the graft [ 47 ]. The reduced macro/micropore size can decrease bone substitution and regeneration [ 48 ]. In the β -TCP group, the presence of osteoclasts and degradation of the matrix in both the central and peripheral zones were noted at 4 and 8 weeks, which is consistent with the results of previous studies.…”

Section: Discussionmentioning

confidence: 99%

Comparison of rhBMP-2 in Combination with Different Biomaterials for Regeneration in Rat Calvaria Critical-Size Defects

Uribe

Vásquez

Alister

et al. 2022

BioMed Research International

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Regeneration of critical bone defects requires the use of biomaterials. The incorporation of osteoinductive agents, such as bone morphogenetic proteins (BMPs), improves bone formation. This study aimed to compare the efficacy of rhBMP-2 in combination with different materials for bone regeneration in critical-sized rat calvarial defects. This was an experimental animal study using 30 rats. In each rat, two 5-mm critical-size defects were made in the calvaria (60 bone defects in total) using a trephine. All rats were randomized to one of the six groups: control (C), autograft + rhBMP-2 (A), absorbable collagen sponge + rhBMP-2 (ACS), β-tricalcium phosphate + rhBMP-2 (B-TCP), bovine xenograft + rhBMP-2 (B), and hydroxyapatite + rhBMP-2 (HA). The outcome was assessed after 4 and 8 weeks using histological description and the histological bone healing scale. Statistical analysis was performed using the Kruskal-Wallis and Mann–Whitney U tests, with a p -value set at 0.05. The average bone healing scores per group were as follows: C group, 12.5; A group, 26.5; ACS group, 18.8; B-TCP group, 26.2; HA group, 20.9; and B group, 20.9. The C group showed a significant difference between weeks 4 and 8 ( p = 0.032 ). Among the 4-week groups, the C group showed a significant difference compared to A ( p = 0.001 ), ACS ( p = 0.017 ), and B-TCP ( p = 0.005 ) groups. The 8-week experimental group did not show any significant differences between the groups. The 5-mm critical size defect in rat calvaria requires the use of bone biomaterials to heal at 4 and 8 weeks. rhBMP-2, as applied in this study, showed no difference in new bone formation when combined with bovine, B-TCP, or HA biomaterials.

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Characterization of Bone Substitute β-TCP Block for Maxillofacial Reconstruction

Cited by 5 publications

References 40 publications

Histological Analysis of Bone Repair in Mandibular Body Osteotomy Using Internal Fixation System in Three Different Gaps without Bone Graft in an Animal Model

Histological Analysis of Bone Repair in Mandibular Body Osteotomy Using Internal Fixation System in Three Different Gaps without Bone Graft in an Animal Model

Channel Aperture Characteristics of Carbonate Apatite Honeycomb Scaffolds Affect Ingrowths of Bone and Fibrous Tissues in Vertical Bone Augmentation

Comparison of rhBMP-2 in Combination with Different Biomaterials for Regeneration in Rat Calvaria Critical-Size Defects

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