Characterization of bone repair in rat femur after treatment with calcium phosphate cement and autogenous bone graft

Puricelli, Edela; Corsetti, Adriana; Ponzoni, Deise; Martins, Gustavo Luís Mamoré; Leite, Mauro Gomes Trein; Santos, Luís Alberto dos

doi:10.1186/1746-160x-6-10

Cited by 13 publications

(18 citation statements)

References 25 publications

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“…An interesting study on the in vitro resorption of three apatite cements (conventional, fast-setting and anti-washout) by osteoclasts if compared with a similar resorption of sintered HA and a cortical bone revealed an intermediate behavior of the cements: they were resorbed slower than bone but faster than HA [362]. Furthermore, bone neo-formation was seen 7 seven days after implantation of an α-TCP cement [363]. The biodegradation rate of the cements might be influenced by ionic substitutions in calcium orthophosphates [364].…”

Section: Bioresorption and Replacement Of The Self-setting Formulatiomentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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Section: Bioresorption and Replacement Of The Self-setting Formulatiomentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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“…Autogenous bone grafts: Also known as autografts, they are obtained from unaffected donor sites from the own receptor individual. The regeneration of the bone defect occurs by mechanisms involving osteogenesis, osteoinduction and osteoconduction [17,46,61,62]. These are the most used grafts due to their biocompatibility and non-immunogenicity, being considered sometimes as standards for bone-grafting [61].…”

Section: Originmentioning

confidence: 99%

Bone Remodeling, Biomaterials And Technological Applications: Revisiting Basic Concepts

Salgado¹,

Sathler²,

Castro³

et al. 2011

JBNB

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Presently, several different graft materials are employed in regenerative or corrective bone surgery. However current misconceptions about these biomaterials, their use and risks may compromise their correct application and development. To unveil these misconceptions, this work briefly reviewed concepts about bone remodeling, grafts classification and manufacturing processes, with a special focus on calcium phosphate materials as an example of a current employed biomaterial. Thus a search on the last decade was performed in Medline, LILACS, Scielo and other scientific electronic libraries using as keywords biomaterials, bone remodeling, regeneration, biocompatible materials, hydroxyapatite and therapeutic risks. Our search showed not only an accelerated biotechnological development that brought significant advances to biomaterials use on bone remodeling treatments but also several therapeutic risks that should not be ignored. The biomaterials specificity and limitations to clinical application point to the current need for developing safer products with better interactions with the biological microenvironments

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“…An interesting study on the in vitro resorption of three apatite-forming formulations (conventional, fast-setting and anti-washout) by osteoclasts if compared with a similar resorption of sintered HA and a cortical bone revealed an intermediate behavior of the formulations: they were resorbed slower than bone but faster than HA [408]. Furthermore, bone neo-formation was seen 7 seven days after implantation of a self-setting α-TCP formulation [409]. The biodegradation rate of the formulations might be influenced by ionic substitutions in calcium orthophosphates [410].…”

Section: Bioresorption and Replacement Of The Self-setting Formulatiomentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2012

Calcium Orthophosphates

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Abstract:In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases form pastes, which set and harden forming either a non-stoichiometric calcium deficient hydroxyapatite or brushite. Since both of them are remarkably biocompartible, bioresorbable and osteoconductive, self-setting calcium orthophosphate formulations appear to be promising bioceramics for bone grafting. Furthermore, such formulations possess excellent molding capabilities, easy manipulation and nearly perfect adaptation to the complex shapes of bone defects, followed by gradual bioresorption and new bone formation. In addition, reinforced formulations have been introduced, which might be described as calcium orthophosphate concretes. The discovery of self-setting properties opened up a new era in the medical application of calcium orthophosphates and many commercial trademarks have been introduced as a result. Currently such formulations are widely used as synthetic bone grafts, with several advantages, such as pourability and injectability. Moreover, their low-temperature setting reactions and intrinsic porosity allow loading by drugs, biomolecules and even cells for tissue engineering purposes. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent bioceramics suitable for both dental and bone grafting applications, has been provided.

show abstract

Characterization of bone repair in rat femur after treatment with calcium phosphate cement and autogenous bone graft

Cited by 13 publications

References 25 publications

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Bone Remodeling, Biomaterials And Technological Applications: Revisiting Basic Concepts

Self-Setting Calcium Orthophosphate Formulations

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