Characterization of antihistamines using biphasic cutaneous reaction in BALB/c mice

Inagaki, Nobuya; Sakurai, Tsuyoshi; Abe, Toru; Musoh, Keiichi; Kawasaki, Hiromu; Tsunematsu, Miwako; Nagai, Hiroichi

doi:10.1016/s0024-3205(98)00356-7

Cited by 15 publications

(10 citation statements)

References 17 publications

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“…The first phase ear swelling appears immediately after the challenge. The first phase response is absent in mast cell-deficient WBB6F1-W/W v mice (17,22) and inhibited by antihistamines (17,23), demonstrating that the response is dependent on mast cells and a mast cell mediator, histamine. Fraction BW separated from mycelium of P. linteus potently inhibited the vascular permeability increase associated with PCA and caused by histamine injection.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of IgE‐dependent Mouse Triphasic Cutaneous Reaction by a Boiling Water Fraction Separated from Mycelium of Phellinus linteus

Inagaki

Shibata

Itoh

et al. 2005

Evidence-Based Complementary and Alternative Medicine

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Phellinus linteus, a mushroom, contains constituents that exhibit potent antitumor effects through activating immune cells. Recently, anti-inflammatory and anti-allergic properties of P. linteus extracts have also been implicated. In the present study, therefore, we separated the constituents of mycelium of P. linteus into five fractions—chloroform-soluble (CF), ethyl acetate-soluble (EA), methanol-soluble (AE), water-soluble (WA) and boiling water-soluble (BW) fractions—and examined their suppressive effects on the IgE-dependent mouse triphasic cutaneous reaction. The triphasic reaction was induced in the ear of BALB/c mice passively sensitized with anti-dinitrophenol IgE by painting with 2,4-dinitrofluorobenzene 24 h later. Ear swelling appeared triphasically with peak responses at 1 h, 24 h and 8 days after the challenge. ME, WA and BW given orally at a dose of 100 mg kg−1 significantly inhibited the first and second phase ear swelling, and BW also inhibited the third phase response. CF only inhibited the second phase. The inhibition by BW was the most potent and almost dose-dependent at doses of 30–300 mg kg−1. BW also inhibited vascular permeability increase caused by passive cutaneous anaphylaxis and histamine, and ear swelling caused by tumor necrosis factor-α. In contrast, BW apparently potentiated the production of interleukin-4 and interferon-γ from anti-CD3-stimulated mouse splenocytes. These results indicate that BW derived from mycelium of P. linteus contains some constituents with anti-allergic as well as immunopotentiating properties.

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Section: Discussionmentioning

confidence: 99%

Inhibition of IgE‐dependent Mouse Triphasic Cutaneous Reaction by a Boiling Water Fraction Separated from Mycelium of Phellinus linteus

Inagaki

Shibata

Itoh

et al. 2005

Evidence-Based Complementary and Alternative Medicine

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“…In the present study, we demonstrated that the IgE-mediated triphasic cutaneous reaction was also evoked in C57BL/6 mice. The first phase reaction, IPR is absent in mast cell-deficient WBB6F1-W/W v mice (Ray et al, 1983;Nagai et al, 1995) and inhibited by antihistamines (Nagai et al, 1995;Inagaki et al, 1998) and platelet-activating factor (PAF) receptor antagonists (Yamaguchi et al, 1998;Yamada et al, 2000). This demonstrates that the IPR is dependent on mast cells and mast cell-derived mediators, histamine and PAF.…”

Section: Discussionmentioning

confidence: 99%

Involvement of cannabinoid CB2 receptors in the IgE-mediated triphasic cutaneous reaction in mice

2007

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“…Previous studies have demonstrated that both histamine and other chemical mediators released from mast cells play a central role in biphasic cutaneous reactions and allergic pruritus [19,20]. In the current investigation, the H 1 receptor antagonist, cetirizine, induced significant inhibition of OVA-induced scratching behavior in experimental animals at a dose of 10 mg/kg.…”

Section: Discussionmentioning

confidence: 48%

Tryptase and protease-activated receptor-2 stimulate scratching behavior in a murine model of ovalbumin-induced atopic-like dermatitis

Zhu

Pan

Wang³

et al. 2015

International Immunopharmacology

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Characterization of antihistamines using biphasic cutaneous reaction in BALB/c mice

Cited by 15 publications

References 17 publications

Inhibition of IgE‐dependent Mouse Triphasic Cutaneous Reaction by a Boiling Water Fraction Separated from Mycelium of Phellinus linteus

Inhibition of IgE‐dependent Mouse Triphasic Cutaneous Reaction by a Boiling Water Fraction Separated from Mycelium of Phellinus linteus

Involvement of cannabinoid CB2 receptors in the IgE-mediated triphasic cutaneous reaction in mice

Tryptase and protease-activated receptor-2 stimulate scratching behavior in a murine model of ovalbumin-induced atopic-like dermatitis

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