Biochemical Pharmacology volume 76, issue 9, P1068-1081 2008 DOI: 10.1016/j.bcp.2008.08.020 View full text
Verena Gelmedin, Rocio Caballero-Gamiz, Klaus Brehm

Abstract: Alveolar echinococcosis (AE), caused by the metacestode larval stage of the fox-tapeworm Echinococcus multilocularis, is a life-threatening disease with very limited treatment options. In search for novel drug targets, we concentrate on factors of the cellular signaling machinery and report herein the characterization of a novel gene, Emmpk2, which is expressed in the parasite's larval stage and which codes for a member of the mitogen-activated protein kinase (MAPK) family. On the amino acid sequence level, th…

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