Characterization and hepatoprotective effect of polysaccharides from Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou sarcocarp

Yue, Yuan; Wu, Shuangchan; Zhang, Huifang; Zhang, Xuyan; Niu, Yunhui; Cao, Xiaoqin; Huang, Farong; Ding, Hong

doi:10.1016/j.fct.2014.09.006

Cited by 62 publications

(39 citation statements)

References 38 publications

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“…It has been reported that many polysaccharides have the activities that scavenge DPPH free radical, hydroxyl radical and hydrogen peroxide [11], protect mice macrophages RAW264.7 against oxidative damage induced by hydrogen peroxide [12]. Moreover, the effect of superoxide dismutase (SOD), one of the representative antioxidant enzymes, in scavenging radicals and reducing oxidative damage could be improved by polysaccharides has been reported [13].…”

mentioning

confidence: 98%

Sulfated polysaccharides from Cyclocarya paliurus reduce H 2 O 2 -induced oxidative stress in RAW264.7 cells

Wang

Xie

Kan

et al. 2015

International Journal of Biological Macromolecules

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mentioning

confidence: 98%

Sulfated polysaccharides from Cyclocarya paliurus reduce H 2 O 2 -induced oxidative stress in RAW264.7 cells

Wang

Xie

Kan

et al. 2015

International Journal of Biological Macromolecules

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“…This plant is widely used in traditional system of medicine for different ailments like diabetes, inflammation, infections, liver diseases, and throat problems by local tribal peoples in India (Naik et al, 2013). Z. jujuba contains phenolic and flavonoid compounds (San and Yildirim, 2010; Wang et al, 2016), polysaccharides (Yue et al, 2014), triterpenoid acids (Guo et al, 2009), alkaloids and glycoside compounds (Meng et al, 2013). Different plant parts of Z. jujuba were reported to have antioxidant (Sun et al, 2011), anti-inflammatory (Yu et al, 2012), hepatoprotective, anti-tumor (Hoshyar et al, 2015) and induction of erythropoietin expression (Lam et al, 2016) activities.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Fraction of Annona reticulata Bark (or) Ziziphus jujuba Root Bark along with Insulin Attenuates Painful Diabetic Neuropathy through Inhibiting NF-κB Inflammatory Cascade

Kandimalla

Dash²,

Kalita

et al. 2017

Front. Cell. Neurosci.

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The present study explains the neuroprotective ability of bioactive fractions of Annona reticulata bark (ARB) and Ziziphus jujuba root bark (ZJ) along with insulin against diabetic neuropathy. By using different solvents of increasing polarity ARB and ZJ were undergone for bioactive guided fractionation. The neuroprotective ability of the all the plant fractions were tested against H2O2 induced toxicity in SHSY5Y neuroblastoma cell lines and DRG neuronal cells. Among all the fractions tested, the methanol extract of ARB and ZJ (ARBME and ZJME) and its water fractions (ARBWF and ZJWF) exhibited significant neuroprotection against H2O2 induced toxicity in SHSY5Y cells and DRG neuronal cells. Further both the active fractions were tested against streptozotocin (55 mg/kg i.p.) induced diabetic neuropathy in male Wistar rats. Body weight changes, blood glucose levels and pain threshold through hot plate, tail immersion, cold plate and Randall-Sillitto methods were measured throughout the study at weekly interval. After completion of the drug treatment period, all the animals were sacrificed to measure the sciatic nerve lipid peroxidation, antioxidative enzyme levels (SOD, catalase, and GSH) and cytokine levels (IL-1β, IL-6, IL-10, TNF-α, iNOS, and NFκB) through ELISA and western blotting analysis. Results of this study explain that ARBME, ZJME, ARBWF, and ZJWF along with insulin potentially attenuate the thermal, mechanical hyperalgesia and cold allodynia in diabetic neuropathic rats, where insulin treatment alone failed to diminish the same. Reduction of sciatic nerve oxidative stress, NF-κB and iNOS mediated inflammatory cascade and normalization of abnormal cytokine release confirms the possible mechanism of action. The present study confirms the neuroprotective ability of ARB and ZJ against painful diabetic neuropathy through inhibiting oxidative stress and NF-κB inflammatory cascade.

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“…[5] It is one of the most popular traditional Chinese medicines extensively used for the treatment of anxiety, insomnia, dreaminess, and night sweats. [6] Recent pharmacological studies indicated that it possesses anti-inflammatory,[78] hepatoprotective,[9] antimicrobial,[1011] anxiolytic,[1213] and hair growth promoting[14] effects. Bioactive essential oil,[81114] saponins,[151617181920] phenolic compounds,[2122] alkaloids,[23] and polysaccharides[2425] have been reported from the seeds of Z. jujuba .…”

Section: Introductionmentioning

confidence: 99%

Chromatographic isolation and spectroscopic identification of phytoconstituents of jujuba seeds (Zizyphus jujuba Mill.)

Alam

Ali

et al. 2017

J Pharm Bioall Sci

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Background:The seeds of Zizyphus jujuba Mill. (Rhamnaceae) are astringent, aphrodisiac, tonic; used to cure cough, asthma, vomiting, burning sensation, biliousness, leucorrhoea, and eye infections in traditional systems of medicine.Materials and Methods:The methanol extract of seeds of Z. jujuba was partitioned into petroleum ether and water soluble fractions. Isolation of compounds was performed by silica gel column chromatography. The structures of isolated compounds were established on the basis of spectral studies and chemical reactions.Results:Chromatographic separation of methanolic extract of seeds yielded three new phyto-constituents characterized as 3, 5, 7-trimethoxy-8, 3′, 4′, 5′-tetrahydroxy flavone-6-oxy hexahydrobisabolene ether (4), 1, 9-dihydroxy tetrahydrogeranyl-8-oxy-O-β-D-glucuronopyranoside (5) and terahydrogeranyl-8-oxy-O-β-D-glucuronopyranosyl (2a→1b)-O-β-D-glucofuranosyl (2b→1c)-O-β-D-glucofuranosyl (2c→1d)-O-β-D-glucopyranosyl (2d→1e)-O-β-D-glucopyranosyl (2c→f)-O-β-D-glucopyranosyl-2f-benzoate (6) along with five known compounds, palmitoyl palmitoleoyl arachidoyl glyceride (1), tetratriacontenoic acid (2), palmitoyl oleoyl linolenoyl glyceride (3), hexanyl tetraglucoside (7) and pentasaccharide (8).Conclusion:This is the first report of saturated monoterpene and sesquiterpene derivatives from jujuba seeds.

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Characterization and hepatoprotective effect of polysaccharides from Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou sarcocarp

Cited by 62 publications

References 38 publications

Sulfated polysaccharides from Cyclocarya paliurus reduce H 2 O 2 -induced oxidative stress in RAW264.7 cells

Sulfated polysaccharides from Cyclocarya paliurus reduce H 2 O 2 -induced oxidative stress in RAW264.7 cells

Bioactive Fraction of Annona reticulata Bark (or) Ziziphus jujuba Root Bark along with Insulin Attenuates Painful Diabetic Neuropathy through Inhibiting NF-κB Inflammatory Cascade

Chromatographic isolation and spectroscopic identification of phytoconstituents of jujuba seeds (Zizyphus jujuba Mill.)

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