Characterization and antioxidant activity of β-carotene loaded chitosan-graft-poly(lactide) nanomicelles

Ge, Wenjiao; Liu, Dong; Chen, Meiwan; Wang, Xiaohui; Liu, Shijie; Sun, Run‐Cang

doi:10.1016/j.carbpol.2014.09.056

Cited by 105 publications

(60 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The addition of thymol to Tween 80 micelles led to a slight increase in the average diameter, compared to the empty micelles. The diameter increase after encapsulating molecules within micelles has also been observed in many other studies182324. This observation indicated that thymol has been successfully incorporated in Tween 80 micelles, which makes the micelle structure more stretched.…”

Section: Resultssupporting

confidence: 76%

“…Ge et al . found that β-carotene micelles showed a higher FRAP value than free carotene24. But the FRAP values were nearly the same after abstracting the micelle blank value.…”

Section: Resultsmentioning

confidence: 93%

“…found that incorporation of eugenol in Tween 20 micelles improved its DPPH radical scavenging activity27. β-carotene incorporated in chitosan-graft-poly (lactide) micelles showed a significantly higher DPPH radical scavenging activity than free β-carotene24. Noipa et al 28.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Physical characterization and antioxidant activity of thymol solubilized Tween 80 micelles

Deng

Taxipalati

Que

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Attempts were made to solubilize thymol in Tween 80 micelle to study the solubilization mechanism of thymol and the effect of solubilization on its antioxidant activity. The maximum solubilized concentration of thymol in a 2.0% (w/v) Tween 80 micelle solution is 0.2 wt%. There was no significant difference in Z-average diameter between the empty micelles and thymol solubilized micelles. 1H NMR spectra indicated that 3-H and 4-H on the benzene ring of thymol interacted with the ester group between the hydrophilic head group and the hydrophobic tail group of Tween 80 by Van der Waals’ force. Ferric reducing antioxidant potential (FRAP) and cupric ion reducing antioxidant capacity (CUPRAC) assays showed that the reducing antioxidant activity of free thymol did not change after solubilized in Tween 80 micelles. Compared to free thymol, the solubilized thymol showed higher activities to scavenge DPPH (2,2-diphenyl-1-picrylhydrazyl) and hydroxyl radicals. The present study suggested a possible preparation of thymol-carrying micelles with enhanced antioxidant activities that could be applied in food beverages.

show abstract

Section: Resultssupporting

confidence: 76%

“…Ge et al . found that β-carotene micelles showed a higher FRAP value than free carotene24. But the FRAP values were nearly the same after abstracting the micelle blank value.…”

Section: Resultsmentioning

confidence: 93%

See 1 more Smart Citation

Physical characterization and antioxidant activity of thymol solubilized Tween 80 micelles

Deng

Taxipalati

Que

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…13 ). Another ternary nanocomposite in which the antioxidant β-carotene was loaded onto self-assembled amphiphilic chitosan-graft-poly(lactide) nanomicelles (14 nm diameter) showed improved stability of the active and enhanced antioxidant effect [ 27 ]. Antioxidant and antibacterial effect was imparted by chitosan deposited layerby-layer onto cellulose fi bers [ 39 ].…”

Section: Loading Active Agents Into Nanochitosanmentioning

confidence: 99%

Nanochitosan and the Skin

Leonida

Kumar

2016

SpringerBriefs in Bioengineering

View full text Add to dashboard Cite

Chitosan is a non-toxic, biodegradable, polycationic polysaccharide, easily obtained from the naturally abundant chitin from the exoskeleton of crustaceans (Fig. 9.1 ) through deacetylation (partial, typically 66-95 %) and partial depolymerization (less extensive). It is a polymeric 2-amino-2-deoxy-β-D-glucan formed through 1→4 glycosidic linkages. The interest in chitosan as delivery vehicle for active species was generated by the knowledge that it is broken down by the enzyme lysozyme in the human body releasing harmless amino sugars [ 1 ], hence biocompatible. The rate and extent of its biodegradability depends on its degree of deacetylation (DD), slower for higher DD values [ 2 ].Great interest in this semisynthetic biopolymer obtained from renewable sources (chitin) stems from its remarkable properties : adhesivity, antimicrobial and antifungal effect, immunity enhancing effect, chelating effect, fi lm and gel forming abilities. As such it found applications in pharmaceuticals, as drug delivery vehicle or vaccine carrier, in biotechnology as gene delivery system, in textiles, spun into fi bers or as a coating, in dentistry, in removal of heavy metals from waste waters, as preservative in the food industry, and many others.Chitosan was found active against both gram positive and gram negative bacteria [ 3 -5 ], and fungi [ 6 ]. This, together with its adhesivity, made it interesting for skin applications as well. High molecular weight chitosans have been found more active against gram positive bacteria while low molecular weight ones were more active against gram negative species [ 7 ]. Positively charged chitosan binds to the negatively charged bacterial membrane, triggering agglutination and/or an increase in its permeability, resulting in leakage of cellular components. The fact that chitosan can chelate metals and thereby contributes to inhibiting some enzymatic activities is also part of its biological activity.Being nontoxic and biocompatible , chitosan has been approved by the FDA for use in wound dressings [ 8 ]. As a wound healing biodegradable material chitosan is

show abstract

“…Besides, the presence of hydroxyl groups in dextran can increase the solubility of the conjugated hydrophobic part that is advantageous for biomedical application . Therefore, the conjugation of dextran and oleic acid may enhance the oral bioavailability of the hydrophobic drug toward the targeted site and reduce the side effects . Here the synthesized copolymer consists of hydrophilic (dextran and carboxylic acid of oleic acid) and hydrophobic segments (long chain methylene group of oleic acid).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of RAFT‐Mediated Amphiphilic Graft Copolymeric Micelle Using Dextran and Poly (Oleic Acid) toward Oral Delivery of Nifedipine

Karmakar

Seesala

Pal

et al. 2018

J. Polym. Sci. Part A: Polym. Chem.

View full text Add to dashboard Cite

A novel, pH‐responsive supramolecular graft copolymeric micelle, composed of dextran and poly (oleic acid), has been synthesized through reversible addition fragmentation chain transfer polymerization with controlled Mn and narrow polydispersity. The structural properties of the copolymer have been studied using FTIR and 1H NMR spectral analyses. Critical micelle concentration (CMC) has been determined fluorometrically and conductometrically. The copolymer shows pH responsive micellar stability, which has been confirmed using DLS study. Dextran‐g‐OA copolymer demonstrates spherical morphology at CMC, while rod‐like assembly has been evidenced beyond CMC that is probably because of the structural alteration of copolymeric chains at higher copolymer concentration. Dextran‐g‐OA is noncytotoxic toward MG‐63 cells. As the self‐assemble nature of copolymer micelle promotes the oral administration of hydrophobic drugs, nifedipine (NFD, a hydrophobic drug) has been used as model drug that has been encapsulated substantially into the core of the micelle. The copolymer releases the loaded NFD at a much slower rate in simulated gastric fluid (pH 1.2) and relatively faster in simulated intestinal fluid (pH 7.4) with a cumulative release of ~95% within 24 h, suggesting an ideal candidate as nifedipine carrier. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 2354–2363

show abstract

Characterization and antioxidant activity of β-carotene loaded chitosan-graft-poly(lactide) nanomicelles

Cited by 105 publications

References 30 publications

Physical characterization and antioxidant activity of thymol solubilized Tween 80 micelles

Physical characterization and antioxidant activity of thymol solubilized Tween 80 micelles

Nanochitosan and the Skin

Synthesis of RAFT‐Mediated Amphiphilic Graft Copolymeric Micelle Using Dextran and Poly (Oleic Acid) toward Oral Delivery of Nifedipine

Contact Info

Product

Resources

About