Characteristics of the minor salivary gland infiltrates in Sjögren's syndrome

Christodoulou, Maria; Kapsogeorgou, Efstathia K.; Moutsopoulos, Haralampos Μ.

doi:10.1016/j.jaut.2009.10.004

Cited by 357 publications

(291 citation statements)

References 37 publications

(24 reference statements)

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“…T-cells predominate in mild lesions, whereas B-cells are the most represented cell subset in the advanced lesions, with a decrease in the percentage of macrophages and an increased percentage of DCs [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Is minor salivary gland biopsy more than a diagnostic tool in primary Sjo¨gren׳s syndrome? Association between clinical, histopathological, and molecular features: A retrospective study

Carubbi

Alunno

Cipriani

et al. 2014

Seminars in Arthritis and Rheumatism

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Section: Introductionmentioning

confidence: 99%

Is minor salivary gland biopsy more than a diagnostic tool in primary Sjo¨gren׳s syndrome? Association between clinical, histopathological, and molecular features: A retrospective study

Carubbi

Alunno

Cipriani

et al. 2014

Seminars in Arthritis and Rheumatism

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“…Indeed, previous microarray studies have shown that, although IFN-induced proteins are differentially expressed in SS salivary glands relative to controls (6), the activities of IFN-α and IFN-γ could not be distinguished (7). The enrichment of activated lymphocytes (robust sources of IFN-γ secretion) in inflamed tissues in the rheumatic diseases (19,20) reinforces the possible contributions of IFN-γ to the IFN signature observed in tissues.…”

Section: Discussionmentioning

confidence: 94%

Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases

Hall¹,

Casciola‐Rosen²,

Berger

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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133

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Elucidating the molecular pathways active in pathologic tissues has important implications for defining disease subsets, selecting therapy, and monitoring disease activity. The development of therapeutics directed at IFN-α or IFN-γ makes the discovery of probes that report precisely on the activity of different IFN pathways a high priority. We show that, although type I and II IFNs induce the expression of a largely overlapping group of molecules, precise probes of IFN-γ activity can be defined. Used in combination, these probes show prominent IFN-γ effects in Sjögren syndrome (SS) tissues. In contrast, dermatomyositis muscle shows a dominant type I IFN pattern. Interestingly, heterogeneity of IFN signatures exists in patients with SS, with some patients demonstrating a predominant type I pattern. The biochemical patterns largely distinguish the target tissues in patients with SS from those with dermatomyositis and provide a relative weighting of the effects of distinct IFN pathways in specific biopsies. In SS, type I and II IFN effects are localized to the same epithelial cells, surrounded by inflammatory cells expressing IFN-γ–induced proteins, suggesting reinforcing interactions. Precise probes of the different IFN pathways active in tissues of complex rheumatic diseases will be critical to classify disease, elucidate pathogenesis, and select therapy.

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“…5C, D). One reason for this phenomenon may be that, as more inflammatory cells infiltrate around salivary glands in patients with Sjögren's syndrome, the CD4 + /CD8 + T lymphocyte ratio further decreases, while the infiltrating CD8 + T lymphocyte count remains unchanged (25). Furthermore, since the total CD4 count in the current patient was originally decreased due to HIV infection, there may have been little CD4 invasion in the lesion as compared with that observed in patients without HIV infection.…”

Section: Ss Coincides With Hiv Infectionmentioning

confidence: 80%

Corticoid Therapy for Overlapping Syndromes in an HIV-positive Patient

et al. 2015

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Human immunodeficiency virus (HIV) infection disturbs the host's immune function and often coexists with various autoimmune and/or systemic rheumatic diseases with manifestations that sometimes overlap with each other. We herein present the case of a 43-year-old Japanese man infected with HIV who exhibited elevated serum creatine kinase and transaminases levels without any symptoms. He was diagnosed with autoimmune hepatitis, polymyositis and Sjögren's syndrome and received combined antiretroviral therapy (cART); however, the laboratory abnormalities persisted. We successfully administered cART with the addition of oral prednisolone, and the patient's condition recovered without side effects related to the metabolic or immunosuppressive effects of these drugs.

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Characteristics of the minor salivary gland infiltrates in Sjögren's syndrome

Cited by 357 publications

References 37 publications

Is minor salivary gland biopsy more than a diagnostic tool in primary Sjo¨gren׳s syndrome? Association between clinical, histopathological, and molecular features: A retrospective study

Is minor salivary gland biopsy more than a diagnostic tool in primary Sjo¨gren׳s syndrome? Association between clinical, histopathological, and molecular features: A retrospective study

Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases

Corticoid Therapy for Overlapping Syndromes in an HIV-positive Patient

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