Characteristics of Polycystic Ovarian Syndrome and Relationship with Ghrelin in Adolescents

Özgen, İlker Tolga; Aydın, Murat; Güven, Ayla; Aliyazıcıoğlu, Yüksel

doi:10.1016/j.jpag.2010.02.011

Cited by 17 publications

(15 citation statements)

References 34 publications

(28 reference statements)

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“…19 Some studies have also reported that reduced plasma ghrelin occurs in association with other insulin-resistant states such as hypertension, type 2 diabetes and polycystic ovary syndrome. 12,13,19,20 A negative correlation between fasting ghrelin and insulin has also been demonstrated. 21 The findings in the present study that ghrelin was negatively associated with systolic and diastolic BP, fasting insulin and HOMA-IR in hypertensive obese patients are consistent with these results.…”

Section: Discussionmentioning

confidence: 90%

Ghrelin and obestatin levels in hypertensive obese patients

Wang

et al. 2014

J Int Med Res

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Objectives: To investigate plasma total ghrelin and obestatin levels and the ghrelin/obestatin ratio prospectively, in hypertensive obese patients. Methods: Height, weight, and waist and hip circumferences were measured in hypertensive and normotensive obese patients and matched healthy controls; the body mass index and waist to hip ratio were calculated. Fasting glucose and insulin levels were measured and the homeostasis model assessment of insulin resistance (HOMA-IR) was determined. Fasting ghrelin and obestatin concentrations were measured by radioimmunoassay and the ghrelin/obestatin ratio was calculated.Results: A total of 38 hypertensive obese patients, 40 normotensive obese patients and 38 controls were enrolled. Hypertensive obese patients had lower plasma levels of ghrelin and obestatin than normotensive obese patients or controls. In addition, normotensive obese patients had lower plasma ghrelin and obestatin levels than controls. In hypertensive obese patients, ghrelin and obestatin levels were negatively associated with systolic and diastolic blood pressure, fasting insulin and HOMA-IR. In normotensive obese patients, ghrelin, obestatin and the ghrelin/obestatin ratio were negatively associated with fasting insulin and HOMA-IR. In both patient groups, fasting obestatin and ghrelin concentrations were significantly and positively correlated with each other. Conclusion: Changes in the levels of ghrelin and obestatin may play a role in the pathophysiology of obesity and hypertension.

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Section: Discussionmentioning

confidence: 90%

Ghrelin and obestatin levels in hypertensive obese patients

Wang

et al. 2014

J Int Med Res

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“…37 In a Turkish study, the insulin resistance ratio in obese adolescent with PCOS was 93.3% vs 46.6% in lean PCOS and 50% in obese controls. 38 Also in another Turkish study, Vural et al 39 found greater frequency of MS and increased carotid artery intima-media thickness in early adulthood in PCOS patients. In their study the prevalence of MS according to WHO guidelines in adolescents with PCOS was 11.6% vs 0 in normal adolescents.…”

Section: Discussionmentioning

confidence: 92%

Association Between Polycystic Ovarian Syndrome, Overweight, and Metabolic Syndrome in Adolescents

Rahmanpour¹,

Jamal²,

Mousavinasab³

et al. 2012

Journal of Pediatric and Adolescent Gynecology

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“…A total of 20 reports met the inclusion criteria and were included in this study(11, 24–41). Since several studies reported the estimates separately according to different categories of BMI (<25 or ≥25), we treated them as from separate studies and incorporated all in the pooling analysis(25, 26, 30, 32, 35, 41). The detailed characteristics of the included studies were demonstrated in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…polycystic ovaries and exclusion of other etiologies (congenital adrenal hyperplasia, androgen-secreting tumors, Cushing’s syndrome) (42). For 3 other included studies(11, 35, 40), the diagnosis of PCOS was confirmed by relevant clinical symptoms and laboratory findings. For example, for Wasko et al(42), the presence of oligomenorrhea or secondary amenorrhea, hyperandrogenemia or clinical evidence of hyperandrogenism was evaluated.…”

Section: Resultsmentioning

confidence: 99%

“…For Schofl et al(11), the diagnosis criteria included clinical symptoms like oligomenorrhea and hirsutism as well as laboratory findings of elevated serum androgen levels and/or elevated LH/FSH ratio. For Ozgen et al(35), adolescents were diagnosed as PCOS if any four of the five criteria were met: oligomenorrhea or amenorrhea existence after two years of menarche; clinical hyperandrogenism; biologic hyperandrogenism; insulin resistance, hyperinsulinism; and microcysts in ovaries or increased ovarian size. The diagnosis criteria in Shi et al were not specified(30).…”

Section: Resultsmentioning

confidence: 99%

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Low circulating ghrelin levels in women with polycystic ovary syndrome: a systematic review and meta-analysis

Gao

Chang

et al. 2016

Endocr J

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Although numerous, human subject studies evaluating the relationship between circulating ghrelin levels and polycystic ovary syndrome (PCOS) risk have yielded inconsistent findings. We aimed to quantitatively assess the association by summarizing all available evidence from human subject studies. The PubMed and Web of Science databases were searched up to February 2015 for eligible studies. Studies were eligible if they reported circulating ghrelin levels in women with PCOS and healthy women controls. A fixed or random-effects model was used to pool risk estimations. Twenty studies including 894 PCOS patients and 574 controls were included in the meta-analysis. The studies had fair methodological quality. The pooling analysis of all available studies revealed that ghrelin levels were significantly lower in PCOS patients than in controls, with standardized mean difference of −0.40 (95% CI: −0.73, −0.08). The significant association persisted in many subgroup strata. However, the heterogeneity across studies was considerable and not eliminated in subgroup analyses. Meta-regression analysis further suggested that the heterogeneity might be relevant to variability in study location, PCOS relevant factors like HOMA-IR ratio, as well as other factors not assessed. In conclusion, our meta-analysis suggested that ghrelin levels were significantly lower in PCOS patients than in controls. Further studies with large sample sizes are warranted to replicate our findings.

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Characteristics of Polycystic Ovarian Syndrome and Relationship with Ghrelin in Adolescents

Cited by 17 publications

References 34 publications

Ghrelin and obestatin levels in hypertensive obese patients

Ghrelin and obestatin levels in hypertensive obese patients

Association Between Polycystic Ovarian Syndrome, Overweight, and Metabolic Syndrome in Adolescents

Low circulating ghrelin levels in women with polycystic ovary syndrome: a systematic review and meta-analysis

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