Characteristics of community-acquired respiratory viruses infections except seasonal influenza in transplant recipients and non-transplant critically ill patients

Lee, Kyoung Hwa; Yoo, Seul Gi; Cho, Yonggeun; Kwon, Da Eun; La, Yeonju; Han, Sanghoon; Kim, Myoung Soo; Choi, Jin Sub; Kim, Soon Il; Kim, Yu Seun; Min, Yoo Hong; Cheong, June Won; Kim, Jin Seok; Song, YoungGoo

doi:10.1016/j.jmii.2019.05.007

Cited by 18 publications

(15 citation statements)

References 34 publications

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“…In addition to seasonal influenza, reported pathogens of pneumonia include adenovirus, coronavirus 229E/NL63/OC43, human bocavirus, human metapneumovirus, parainfluenza virus 1/2/3, rhinovirus and respiratory syncytial virus A/B [15][16][17][18] . Moreover, these viruses can cause co-infection in the setting of communityacquired bacterial pneumonia [16][17][18] .…”

Section: Sars-cov-2 and Covid-19mentioning

confidence: 99%

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges

Lai

Shih

et al. 2020

International Journal of Antimicrobial Agents

5,228

4,340

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Section: Sars-cov-2 and Covid-19mentioning

confidence: 99%

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges

Lai

Shih

et al. 2020

International Journal of Antimicrobial Agents

5,228

4,340

View full text Add to dashboard Cite

“…13,14 Previous studies demonstrated that HCoV-NL63 infection is more common in adults than in children. 15,16 This finding suggests there may indeed be relative resistance to SARS-CoV-2 in children.…”

mentioning

confidence: 93%

Are children less susceptible to COVID-19?

Lee

Chen

et al. 2020

Journal of Microbiology, Immunology and Infection

592

530

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“…Indeed, a recently published phase III clinical trial showed that BCG vaccination decreases the prevalence of infections, mostly respiratory, in the elderly (50). Thus, due to the induction of trained immunity, BCG may be an excellent candidate to approach outbreaks caused by respiratory pathogens without commercial vaccines available, such as hRSV, hMPV, parainfluenza, adenovirus, rhinovirus, and coronavirus (51)(52)(53)(54)(55)(56). The world is currently living a pandemic caused by a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) that causes millions of coronavirus disease (COVID-19) cases that can lead to the development of pneumonia and even death (57,58).…”

Section: Trained Immunity Induced By Bcgmentioning

confidence: 99%

“…The induction of trained immunity-related cytokines, such as IL-6, TNF, and IL-1b by these vaccines still has to be elucidated (3). Besides hRSV and hMPV, there are other important respiratory viruses, as parainfluenza, adenovirus, rhinovirus, and the newly identified SARS-CoV-2, among others (51)(52)(53)(54)(55)(56)100). The unspecific protection mediated by the development of trained immunity may be a good strategy to protect against a broad spectrum of viruses, being recombinant BCGs excellent candidates, since BCG is a safe vaccine used to immunize infants, which constitute a high-risk population (101).…”

Section: Trained Immunity Induced By Recombinant Vaccinesmentioning

confidence: 99%

Induction of Trained Immunity by Recombinant Vaccines

et al. 2021

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Vaccines represent an important strategy to protect humans against a wide variety of pathogens and have even led to eradicating some diseases. Although every vaccine is developed to induce specific protection for a particular pathogen, some vaccine formulations can also promote trained immunity, which is a non-specific memory-like feature developed by the innate immune system. It is thought that trained immunity can protect against a wide variety of pathogens other than those contained in the vaccine formulation. The non-specific memory of the trained immunity-based vaccines (TIbV) seems beneficial for the immunized individual, as it may represent a powerful strategy that contributes to the control of pathogen outbreaks, reducing morbidity and mortality. A wide variety of respiratory viruses, including respiratory syncytial virus (hRSV) and metapneumovirus (hMPV), cause serious illness in children under 5 years old and the elderly. To address this public health problem, we have developed recombinant BCG vaccines that have shown to be safe and immunogenic against hRSV or hMPV. Besides the induction of specific adaptive immunity against the viral antigens, these vaccines could generate trained immunity against other respiratory pathogens. Here, we discuss some of the features of trained immunity induced by BCG and put forward the notion that recombinant BCGs expressing hRSV or hMPV antigens have the capacity to simultaneously induce specific adaptive immunity and non-specific trained immunity. These recombinant BCG vaccines could be considered as TIbV capable of inducing simultaneously the development of specific protection against hRSV or hMPV, as well as non-specific trained-immunity-based protection against other pathogenic viruses.

show abstract

Characteristics of community-acquired respiratory viruses infections except seasonal influenza in transplant recipients and non-transplant critically ill patients

Cited by 18 publications

References 34 publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges

Are children less susceptible to COVID-19?

Induction of Trained Immunity by Recombinant Vaccines

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