Characteristics, management of the neck, and oncological outcomes of malignant minor salivary gland tumours in the oral and sinonasal regions

Lee, So-Yoon; Shin, Hyang Ae; Rho, Kyung Jin; Chung, Hyo Jin; Kim, Se‐Heon; Choi, Eun Chang

doi:10.1016/j.bjoms.2012.05.004

Cited by 24 publications

(32 citation statements)

References 22 publications

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“…The incidence of clinically evident metastases at diagnosis of head and neck AdCC is variable depending on the series and site of origin of the tumor but usually ranges between 3% and 16% [1,2,4–6,8,10–13,15–20,22–29] (Table 4). One of the reasons that overall reported occurrence of lymph node metastasis is rare for AdCC from different published series may be that the two most common sites for AdCC, the parotid gland and hard palate, have low propensity for nodal spread.…”

Section: Incidence and Consequences Of Cervical Lymph Node Metastasismentioning

confidence: 99%

“…It is very rare in patients who received therapeutic or elective neck dissections [1,10,20], or postoperative radiotherapy (RT) to the neck [8,18]. …”

Section: Incidence and Consequences Of Cervical Lymph Node Metastasismentioning

confidence: 99%

“…The most common malignant histologic types are adenoid cystic carcinoma (AdCC) (24–70%) and mucoepidermoid carcinomas (11–39%). Other subtypes, such as adenocarcinoma, acinic cell carcinoma, myoepithelial carcinoma, and malignant mixed tumor (carcinoma arising from pleomorphic adenomas), occur less frequently [1–5] (Table 1). …”

Section: Introductionmentioning

confidence: 99%

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Cervical lymph node metastasis in adenoid cystic carcinoma of oral cavity and oropharynx: A collective international review

et al. 2016

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The purpose of this study was to establish general guidelines in the management of the N0 neck of oral cavity and oropharyngeal adenoid cystic carcinoma (AdCC) in order to improve the survival of these patients and/or reduce the risk of neck recurrences. The incidence of cervical node metastasis at diagnosis of head and neck AdCC is variable, and ranges between 3% and 16%. Metastasis to the cervical lymph nodes of intraoral and oropharyngeal AdCC varies from 2% to 43%, with the lower rates pertaining to palatal AdCC and the higher rates to base of the tongue. Neck node recurrence may happen after treatment in 0–14% of AdCC, is highly dependent on the extent of the treatment and is very rare in patients who have been treated with therapeutic or elective neck dissections, or elective neck irradiation. Lymph node involvement with or without extracapsular extension in AdCC has been shown in most reports to be independently associated with decreased overall and cause-specific survival, probably because lymph node involvement is a risk factor for subsequent distant metastasis. The overall rate of occult neck metastasis in patients with head and neck AdCC ranges from 15% to 44%, but occult neck metastasis from oral cavity and/or oropharynx seems to occur more frequently than from other locations such as the sinonasal tract and major salivary glands. Nevertheless, the benefit of elective neck dissection (END) in AdCC is not comparable to that of squamous cell carcinoma, because the main cause of failure is not related to neck or local recurrence, but rather, to distant failure. Therefore, END should be considered in patients with a cN0 neck with AdCC in some high risk oral and oropharyngeal locations when postoperative RT is not planned, or the rare AdCC-high grade transformation.

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Section: Incidence and Consequences Of Cervical Lymph Node Metastasismentioning

confidence: 99%

“…It is very rare in patients who received therapeutic or elective neck dissections [1,10,20], or postoperative radiotherapy (RT) to the neck [8,18]. …”

Section: Incidence and Consequences Of Cervical Lymph Node Metastasismentioning

confidence: 99%

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Cervical lymph node metastasis in adenoid cystic carcinoma of oral cavity and oropharynx: A collective international review

et al. 2016

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“…Minor salivary gland tumors, while relatively uncommon, are frequently malignant [27][28][29][30]. They most often present at the hard palate, but can occur at a range of sites in the oral cavity, oropharynx, and sinonasal region that are difficult to access [27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

“…They most often present at the hard palate, but can occur at a range of sites in the oral cavity, oropharynx, and sinonasal region that are difficult to access [27][28][29][30][31][32]. Complete surgical resection is recommended, often followed by adjuvant radiation, except in early stage tumors excised with negative margins with no adverse pathological features [30,[33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Transoral endoscopic head and neck surgery (eHNS) for minor salivary gland tumors of the oropharynx

et al. 2017

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Background: Transoral endoscopic head and neck surgery (eHNS), including transoral laser microsurgery (TLM) and transoral robotic surgery (TORS), provides access to subsites in the head and neck that have traditionally been difficult to approach. Minor salivary gland tumors, while relatively uncommon, are frequently malignant and can occur at sites in the oropharynx accessible by transoral eHNS. Presented here is the largest review to date of patients with minor salivary gland tumors of the oropharynx managed with transoral eHNS as primary or salvage therapy. Methods: A retrospective chart review was performed, including data from 20 patients with minor salivary gland tumors of the oropharynx managed with transoral eHNS at 2 tertiary, academic medical centers. Details of tumor pathology, margin analysis, adjuvant therapy, and an assessment of oncologic outcome were included. Results: The base of tongue was the most common tumor site (75%). Adenoid cystic carcinoma (ACC) accounted for most cases (35%), and negative margins were obtained in most (95%) through an endoscopic-only approach. Overall, 50% of patients received post-operative radiation therapy. Postoperative complications were limited, with one patient (5%) returning to the OR for control of post-operative oropharyngeal bleeding. On average follow-up of 36 months, 90% of patients were alive with no evidence of recurrence.

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Nineteen‐year oncologic outcomes and the benefit of elective neck dissection in salivary gland adenoid cystic carcinoma

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Characteristics, management of the neck, and oncological outcomes of malignant minor salivary gland tumours in the oral and sinonasal regions

Cited by 24 publications

References 22 publications

Cervical lymph node metastasis in adenoid cystic carcinoma of oral cavity and oropharynx: A collective international review

Cervical lymph node metastasis in adenoid cystic carcinoma of oral cavity and oropharynx: A collective international review

Transoral endoscopic head and neck surgery (eHNS) for minor salivary gland tumors of the oropharynx

Nineteen‐year oncologic outcomes and the benefit of elective neck dissection in salivary gland adenoid cystic carcinoma

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